Table 1.

Comparison of characteristics between subgroups (all comparisons were made between individual subgroups and the AA nontrait subgroup)a

SubgroupAA NontraitAA SCTP Value AA SCT versus AA NontraitAA Hemoglobin C TraitP Value AA Hemoglobin C Trait versus AA NontraitEAP Value for EA versus AA Nontrait
N24511021445
Age (years), mean ± SD56.5 ± 13.354.0 ± 13.90.02553.8 ± 17.00.2757.6 ± 16.70.37
Gender (% male)31.839.10.1938.10.6350.60.0001
Glucose
    mmol/L9.55 ± 5.678.60 ± 4.550.4010.1 ± 5.380.419.10 ± 4.940.27
    mg/dl172 ± 102155 ± 82181 ± 97164 ± 89
HbA1c (%), initial value mean ± SD8.3 ± 2.28.2 ± 1.90.638.7 ± 2.80.297.6 ± 1.70.005
Serum potassium (mmol/L), mean ± SD4.20 ± 0.514.25 ± 0.480.464.40 ± 0.610.124.44 ± 0.530.0001
Serum bicarbonate (mmol/L), mean ± SD27.2 ± 3.126.9 ± 2.90.3828.8 ± 2.80.04226.9 ± 3.40.30
Blood urea nitrogen, mean ± SD
    mmol/L6.57 ± 3.86.57 ± 5.00.996.18 ± 3.00.707.78 ± 4.90.0008
    mg/dl18.4 ± 10.618.4 ± 14.017.3 ± 8.421.8 ± 13.7
Initial eGFR (ml/min/1.73m2), mean ± SD69.3 ± 29.771.5 ± 28.20.4977.8 ± 24.90.1758.7 ± 25.20.0001
Median urinary albumin:creatinine ratio, initial measurement18.524.00.231040.00620.00.33
Median of mean of all urinary albumin:creatinine ratio measurements29.5450.111130.01535.50.11
Proportion of individuals with urinary albumin:creatinine ratio >30012.8% (n = 156)16.0% (n = 75)0.5538.5% (n = 13)0.02712.0% (n = 284)0.88
Median urinary protein:creatinine ratio, initial measurement0.400.220.520.290.730.210.52
Median of mean of all urinary protein:creatinine ratio measurements0.710.480.980.290.490.470.85
Proportion of individuals with a urinary protein:creatinine ratio >0.266.2% (n = 71)62.1% (n = 29)0.8260% (n = 5)0.9966.9% (n = 130)0.99
Median normalized urinary protein:creatinine ratio, initial measurement0.730.950.32.680.0250.770.66
Median normalized urinary protein excretion1.471.670.453.470.101.520.30
Proportion of individuals who ever had hematuria8/243 (3.3%)2/105 (1.9%)0.732/20 (10%)0.179/413 (2.2%)0.45
  • a P value is for comparison with reference group of AA without SCT.