Table 1.

Patient characteristics according to baseline PF4-H-AB status

VariableGroup 1: Negative PF4-H-AB Test (n = 1005)Group 2: Positive PF4-H-AB Test (n = 231)Pa
Age (years; mean [SD])65.5 ± 8.366.3 ± 8.20.299
Gender (male/female)548/457118/1130.495
Ever smoked (% [n])42 (418)36 (83)0.213
BMI (kg/m2; mean [SD])27.4 ± 4.828.0 ± 4.70.067
SBP (mmHg; mean [SD])146 ± 22145 ± 220.460
DBP (mmHg; mean [SD])76 ± 1176 ± 110.817
Ultrafiltration volume (kg; median [25th to 75th percentiles])2.0 (1.5 to 3.0)2.0 (1.0 to 3.0)0.443
Hemodialysis shunt (% [n])94 (944)90 (208)0.045
Central venous dialysis catheter (% [n])6 (60)10 (23)0.045
Time on dialysis (months; mean [SD])8.6 ± 7.16.7 ± 5.8<0.001
History ofb
    arrhythmia (% [n])17 (174)25 (57)0.017
    MI, CABG, PCI, or CHDc (% [n])29 (293)30 (69)0.811
    CHF (% [n])d34 (345)39 (91)0.210
    stroke or TIA18 (158)16 (37)0.383
    peripheral vascular disease (% [n])45 (453)42 (98)0.512
Hemoglobin (g/dl; mean [SD])10.9 ± 1.310.8 ± 1.40.394
Platelets (1000/μl; mean [SD])257 ± 80259 ± 840.608
HbA1c (%; mean [SD])6.74 ± 1.276.63 ± 1.220.225
Phosphate (mg/L; mean [SD])6.02 ± 1.596.08 ± 1.660.453
Albumin (g/dl; mean [SD])3.83 ± 0.313.77 ± 0.280.016
CRP (mg/L; median [25th to 75th percentiles])4.9 (2.2 to 12.0)5.6 (2.6 to 14.2)0.042
LDL cholesterol (mg/dl; mean [SD])125 ± 29128 ± 320.211
  • To convert hemoglobin values to millimoles per liter, multiply by 0.62. To convert platelet values to platelets per liter, multiply by 106. To convert values for phosphate to millimoles per liter, multiply by 0.32. To convert values for LDL cholesterol to millimoles per liter, multiply by 0.03. BMI, body mass index; CABG, coronary artery bypass grafting surgery; CHD, coronary heart disease; CHF, congestive heart failure; DBP, diastolic BP; HbA1c, glycated hemoglobin; PCI, percutaneous coronary intervention; SBP, systolic BP; TIA, transient ischemic attack.

  • a P values for comparison between groups of patients with positive and negative PF4-H-AB test at baseline were derived from a general linear model for continuous variables or logistic regression for categorical variables both adjusted for age and gender, as appropriate.

  • b Types of disease and intervention are not mutually exclusive.

  • c Documented by coronary angiography.

  • d Predominantly New York Heart Association class II.