Table 4.

Associations between baseline risk factors and cardiovascular events and death

ParameterIncrement or Reference CategoryUnadjusted (HR [95% CI])PAdjusted, Model 1 (HR [95% CI])PAdjusted, Model 2 (HR [95% CI])P
Cardiovascular event or death (99/596)
    LVMI21.8 g/m21.13 (1.00 to 1.27)0.041.14 (1.01 to 1.29)0.03
    age6.3 years1.24 (1.13 to 1.35)<0.011.23 (1.13 to 1.35)<0.011.24 (1.11 to 1.39)<0.01
    diabetic renal diseaseGN2.85 (1.54 to 5.26)<0.011.90 (1.00 to 3.61)0.052.31 (1.04 to 5.14)0.04
    “other” renal diseaseGN1.91 (1.07 to 3.42)0.03
    catheterFistula1.73 (1.01 to 2.97)0.05
    epoetin dosage1000 U1.05 (1.01 to 1.09)<0.011.06 (1.02 to 1.10)<0.01
    SBP13.5 mmHg1.16 (1.02 to 1.32)0.021.16 (1.02 to 1.32)0.021.19 (1.02 to 1.39)0.03
    Hb0.4 g/dl0.92 (0.87 to 0.98)0.010.92 (0.86 to 0.98)0.01
    serum albumin0.1 g/dl0.90 (0.85 to 0.95)<0.010.91 (0.86 to 0.97)<0.01
    BNP76 ng/ml1.03 (1.01 to 1.04)<0.011.03 (1.02 to 1.05)<0.011.03 (1.01 to 1.05)<0.01
    Troponin T0.005 ng/ml1.01 (1.00 to 1.02)0.02
Cardiovascular event (78/596)
    LVMI21.8 g/m21.15 (1.00 to 1.31)0.05
    fractional shortening5.5%0.87 (0.76 to 1.00)0.05
    age6.3 years1.29 (1.17 to 1.43)<0.011.29 (1.16 to 1.42)<0.011.33 (1.17 to 1.52)
    diabetic renal diseaseGN2.99 (1.48 to 6.04)<0.01
    “other” renal diseaseGN2.03 (1.04 to 3.95)0.04
    epoetin dosage1000 U1.05 (1.00 to 1.10)0.031.06 (1.01 to 1.10)0.02
    SBP13.5 mmHg1.25 (1.08 to 1.44)<0.011.25 (1.08 to 1.44)<0.011.30 (1.09 to 1.55)<0.01
    serum albumin0.1 g/dl0.91 (0.85 to 0.97)<0.010.93 (0.87 to 1.00)0.05
    BNP76 ng/ml1.02 (1.00 to 1.04)0.03
Death (33/596)
    age6.3 years1.19 (1.03 to 1.38)0.021.19 (1.02 to 1.37)0.02
    diabetic renal diseaseGN3.03 (1.03 to 8.86)0.04
    catheterFistula3.84 (1.81 to 8.16)<0.012.58 (1.03 to 6.44)0.04
    epoetin dosage1000 U1.08 (1.02 to 1.15)0.011.09 (1.02 to 1.15)<0.01
    Hb0.4 g/dl0.83 (0.75 to 0.93)<0.01
    serum albumin0.1 g/dl0.83 (0.77 to 0.90)<0.010.84 (0.77 to 0.91)<0.010.89 (0.79 to 1.00)0.05
    BNP76 ng/ml1.04 (1.03 to 1.06)<0.011.05 (1.03 to 1.07)<0.011.03 (1.01 to 1.05)0.01
    Troponin T0.005 ng/ml1.01 (1.00 to 1.02)<0.011.01 (1.00 to 1.02)0.02
    C-reactive protein1 mg/L1.02 (1.00 to 1.04)0.011.02 (1.01 to 1.04)<0.01
  • Parameter estimates for continuous variables were computed for intervals equal to one half the interquartile range. All of the variables shown in Table 1 were considered, except serial BP levels; only those with P < 0.05 are shown. Model 1 adjusted for age and gender; model 2 adjusted for age, gender, and variables with P < 0.05 in model 1. GN, glomerulonephritis; FS, fractional shortening; HR, hazard ratio.