Table 4.

HRs of 5-year mortality according to four increments of dietary phosphorus to protein intake ratio in 224 MHD patients (October 2001 to January 2007)

Death HR (95% CI) [P]Dietary Phosphorus to Protein Ratio (mg/g)P for Trend
<12 (n = 33)12 to <14 (n = 64)14 to <16 (n = 45)≥16 (n = 82)
Unadjusted0.73 (0.32, 1.66) [0.45]1.001.46 (0.76, 2.83) [0.25]1.55 (1.01, 2.68) [0.06]0.02
Case-mixa adjusted0.83 (0.35, 1.99) [0.67]1.001.56 (0.74, 3.28) [0.24]1.74 (1.06, 3.13) [0.04]0.02
Case-mix + dietb + serum phosphorus0.88 (0.36, 2.16) [0.78]1.001.50 (0.70, 3.20) [0.29]2.09 (1.08, 4.05) [0.03]0.02
Case-mix + diet + MICSc + inflammationd adjusted1.13 (0.41, 3.12) [0.81]1.001.80 (0.77, 4.22) [0.17]1.99 (1.03, 4.25) [0.02]0.08
  • a Case-mix variables include age, gender, race/ethnicity, diabetes, dialysis vintage, insurance (Medicare), marital status, modified Charlson comorbidity score, dialysis dose (Kt/V), intake of sevelamer HCl or calcium-based binders, and kidney residual urine.

  • b Diet includes calorie, protein, and potassium intakes.

  • c MICS variables include albumin, erythropoietin dose, creatinine, hemoglobin, serum phosphorus, nPCR, bicarbonate, calcium, ferritin, white blood cell, lymphocyte percent, body mass index, and vitamin D dose.

  • d Inflammatory markers include CRP, IL-6, and TNF-α.