Table 4.

ORs of transfusion by treatment group for each level of change in Hb

TreatmentChange in Hb Since Last Outpatient Measurement (g/dl; OR [95% CI])
Increase of 0.0 to 4.0 (Observation = 325,219)Decrease of 0.1 to 0.9 (Observation = 187,309)Decrease of 1.0 to 1.9 (Observation = 118,465)Decrease of 2.0 to 2.9 (Observation = 54,337)Decrease of 3.0 to 5.0 (Observation = 34,658)
No therapyReferenceReferenceReferenceReferenceReference
Iron only0.61 (0.58 to 0.63)0.44 (0.42 to 0.45)0.45 (0.43 to 0.47)0.48 (0.45 to 0.51)0.49 (0.45 to 0.54)
ESA only0.61 (0.59 to 0.63)0.44 (0.43 to 0.46)0.45 (0.43 to 0.47)0.47 (0.44 to 0.50)0.48 (0.44 to 0.52)
ESA+iron0.60 (0.58 to 0.63)0.44 (0.42 to 0.45)0.45 (0.43 to 0.46)0.47 (0.44 to 0.50)0.48 (0.44 to 0.52)
  • These analyses were conducted with multiple Hb measurements per patient. Model was adjusted for repeated measures and values of patient age; gender; eGFR; ICD-9–coded anemia and CKD; inpatient length of stay or outpatient status; nephrology and hematology care; and various comorbidities including diabetes, CAD, and CHF updated at the time of Hb measurement.