Table 1.

Demographic and baseline characteristics (modified intent-to-treat analysis set)

QW (n = 107)Q2W (n = 106)Q4W (n = 215)Total (n = 428)
Sex, n (%)
    N107106215428
    male40 (37.4)34 (32.1)89 (41.4)163 (38.1)
    female67 (62.6)72 (67.9)126 (58.6)265 (61.9) Race, n (%)
    N107106215428
    white57 (53.3)63 (59.4)125 (58.1)245 (57.2)
    black43 (40.2)35 (33.0)72 (33.5)150 (35.0)
    Asian4 (3.7)2 (1.9)7 (3.3)13 (3.0)
    other3 (2.8)6 (5.7)11 (5.1)20 (4.7)
Age
    N107106215428
    ≤65 yrs, n (%)36 (33.6)29 (27.4)63 (29.3)128 (29.9)
    >65 yrs, n (%)71 (66.4)77 (72.6)152 (70.7)300 (70.1)
    mean (SD), yrs70.4 (13.04)71.7 (10.68)71.1 (12.48)71.1 (12.18)
    median, yrs71.072.072.072.0
    range, yrs(23; 93)(45; 96)(33; 96)(23; 96)
Weight, kg
    N106106212424
    mean (SD)82.8 (18.25)84.2 (20.58)87.2 (22.43)85.3 (21.04)
    median79.481.983.882.5
    range(49; 141)(43; 149)(38; 188)(38; 188)
Baseline weight tertiles for mITT, n (%)
    N106106212424
    ≤74.0 kg40 (37.7)39 (36.8)64 (30.2)143 (33.7)
    >74.0 to ≤91.0 kg35 (33.0)32 (30.2)73 (34.4)140 (33.0)
    >91.0 kg31 (29.2)35 (33.0)75 (35.4)141 (33.3)
Height, cm
    N107106213426
    mean (SD)164.0 (10.32)163.3 (11.12)165.0 (10.55)164.3 (10.64)
    median163.0162.6165.1163.8
    range(136; 185)(125; 195)(127; 193)(125; 195)
Baseline GFR, ml/min per 1.73 m2
    N107106215428
    mean (SD)27.83 (10.742)28.75 (9.855)27.90 (9.698)28.09 (9.990)
    median24.0029.5026.0026.00
    range(15.0; 76.0)(14.0; 59.0)(15.0; 57.0)(14.0; 76.0)
Baseline GFR category, n (%)
    N107106215428
    <15 ml/min per 1.73 m201 (0.9)01 (0.2)
    ≥15 to <30 ml/min per 1.73 m272 (67.3)52 (49.1)136 (63.3)260 (60.7)
    ≥30 to <60 ml/min per 1.73 m234 (31.8)53 (50.0)79 (36.7)166 (38.8)
    ≥60 ml/min per 1.73 m21 (0.9)001 (0.2)
Baseline hemoglobin, g/dl
    N107106215428
    mean (SD)11.03 (0.602)11.12 (0.586)11.17 (0.558)11.12 (0.577)
    median11.0011.2011.2011.20
    range(10.0; 11.9)(10.0; 11.9)(10.0; 11.9)(10.0; 11.9)
Baseline Hb tertiles for mITT, n (%)
    N107106215428
    ≤10.9 g/dl49 (45.8)36 (34.0)70 (32.6)155 (36.2)
    >10.9 to ≤11.5 g/dl29 (27.1)39 (36.8)76 (35.3)144 (33.6)
    >11.5 g/dl29 (27.1)31 (29.2)69 (32.1)129 (30.1)
Baseline ferritin level, pmol/L
    N107106215428
    mean (SD)513.97 (486.054)518.60 (388.698)558.97 (434.965)537.72 (437.124)
    median352.00412.50436.00402.50
    range(29.0; 2136)(35.0; 1571)(15.0; 2387)(15.0; 2387)
Baseline ferritin tertiles/mITT, n (%)
    N107106215428
    ≤264 pmol/L42 (39.3)33 (31.1)68 (31.6)143 (33.4)
    >264 to ≤605 pmol/L32 (29.9)44 (41.5)68 (31.6)144 (33.6)
    >605 pmol/L33 (30.8)29 (27.4)79 (36.7)141 (32.9)
  • mITT, modified intent to treat.