Table 2.

Biochemical parameters at baseline, 2nd, 4th and 6th weeks and at the washout in patients treated with calcium acetate (n = 19) or sevelamer hydrochloride (n = 21)

Laboratory ParameterCalcium Acetate GroupSevelamer Hydrochloride Group
BaselineWeek 2Week 4Week 6WashoutBaselineWeek 2Week 4Week 6Washout
P (mg/dl)3.61 ± 0.543.52 ± 0.523.54 ± 0.723.50 ± 0.643.68 ± 0.623.45 ± 0.653.49 ± 0.733.37 ± 0.653.31 ± 0.633.53 ± 0.61
Ca (mg/dl)9.34 ± 0.569.29 ± 0.559.45 ± 0.509.38 ± 0.529.33 ± 0.569.24 ± 0.459.36 ± 0.449.30 ± 0.439.27 ± 0.539.26 ± 0.42
Cr (mg/dl)2.52 ± 0.762.39 ± 0.712.44 ± 0.702.56 ± 0.692.47 ± 0.692.59 ± 0.822.43 ± 0.682.48 ± 0.722.42 ± 0.722.37 ± 0.75
TAP (U/L)84.42 ± 25.3281.95 ± 22.6188.11 ± 26.3389.05 ± 32.8780.58 ± 24.7378.29 ± 18.0180.71 ± 19.7692.57 ± 56.64102.6 ± 76.22a83.95 ± 25.41
BAP (U/L)36.91 ± 12.6237.94 ± 13.79b33.46 ± 10.3538.56 ± 16.41a,b
DPD (nmol/L)9.81 ± 3.259.62 ± 3.69b10.8 ± 3.5210.25 ± 3.062
25vitD (ng/ml)35.71 ± 18.6633.27 ± 13.60b33.88 ± 22.7328.64 ± 19.76a,b
1,25vitD (pg/ml)32.82 ± 16.6734.59 ± 18.5631.26 ± 11.0428.55 ± 13.5043.72 ± 34.2029.79 ± 25.0829.70 ± 17.2632.26 ± 21.8830.42 ± 14.9732.92 ± 16.16
PTH (pg/ml)89 (52 to 141)95 (64 to 110)76 (43 to 105)75 (40 to 110)a108 (63 to 146)107 (76 to 130)102 (60 to 147)77 (51 to 126)69 (47 to 94)a105 (63 to 146)
FGF23 (pg/ml)97 (62 to 148)60 (39 to 91)90 (46 to 135)77 (56 to 120)b87 (65 to 144)103 (62 to 142)90 (52 to 124)60 (41 to 145)54 (38 to 94)a,b93 (46 to 125)
uCa (mg/24 h)23.39 ± 24.4923.47 ± 17.5830.11 ± 21.6835.93 ± 14.7324.28 ± 14.7925.11 ± 27.2731.8 ± 27.6129.71 ± 30.5636.71 ± 30.5835.24 ± 42.19
uP (mg/24 h)445 ± 155400 ± 182380 ± 144a244 ± 121a478 ± 152534 ± 137401 ± 139346 ± 160a313 ± 135a464 ± 197
FeP (%)58.2 ± 37.242.3 ± 30.835.5 ± 22.1a27.1 ± 13.3a47.5 ± 25.061.0 ± 28.469.3 ± 52.952.6 ± 38.7a35.8 ± 25.9a62.7 ± 42.7
  • Data are expressed as mean ± SD [except for PTH and FGF23, which are expressed as median (25th to 75th percentile interval)].

  • a Within-group change from baseline; P < 0.05.

  • b Between-group change; P < 0.05.