Table 7.

Multivariate Cox proportional hazards analysis of association of the rs2808630 genotypes and composite outcomes and other clinical predictors

VariableHazard Ratio (95% CI)P Valuea
Genotype
    rs2808630_AARef
    rs2808630_AG0.87 (0.59, 1.29)0.49
    rs2808630_GG3.65 (1.62, 8.23)0.002b
BP assignmentc0.78 (0.55, 1.12)0.19
Drug assignment
    Calcium channel blockersRef
    β blockers0.72 (0.44, 1.17)0.19
    ACE inhibitors0.56 (0.34, 0.91)0.02
Log CRP (mg/dl)0.96 (0.81, 1.14)0.65
Age1.01 (0.99, 1.02)0.53
Genderd1.04 (0.71, 1.52)0.83
Body mass index (kg/m2)0.98 (0.95, 1.02)0.32
Mean baseline GFR (ml/min)0.96 (0.94, 0.97)<0.0001
Urine protein (g/d)1.88 (1.64, 2.17)<0.0001
Number of comorbidities1.04 (0.85, 1.26)0.72
Smoking (current versus never or former)1.63 (1.11, 2.40)0.01
  • Adjustement done for baseline covariates.

  • BP assignment: usual: MAP 102–107 mmgh; low: MAP <92 mmgh.

  • Mean baseline GFR: the mean of two GFR measurements by isothalamate.

  • a Unadjusted for multiple comparisons.

  • b Statistical significance at an α = 0.0045 after Bonferroni correction for 11 genotypes.

  • c Reference group low BP.

  • d Reference group male.