Table 5.

Association of CRP polymorphisms and renal outcomes

CRP SNPs and GenotypeNComposite of Halving Your GFR, Reaching ESRD, or Death
Hazard Ratio (95% CI)P Valuesa
rs2808630
AA439Ref
AG1910.87 (0.59–1.29)0.49
GG153.65 (1.62–8.23)0.002b
rs1205
GG447Ref
AG1791.14 (0.74–1.52)0.48
AA250.90 (0.36–2.27)0.84
ss3093066
CC399Ref
AC2131.02 (0.6–1.5)0.89
AA371.23 (0.6–2.5)0.56
rs1417938
AA503Ref
AT1410.89 (0.58–1.37)0.62
TT61.07 (0.14–7.89)0.94
rs3093058
AA423Ref
AT2040.81 (0.55–1.19)0.28
TT200.92 (0.28–3.02)0.89
rs1800947
GG644Ref
CG70.19 (0.03–1.14)0.11
CCNANA
  • Composite outcome = decrease in GFR by 50% or a drop in the GFR ≥25 ml/min per 1.73 m2, ESRD, or death.

  • Hazard ratios are adjusted for age, gender, BP treatment assignment, drug treatment assignment, body mass index, baseline GFR, baseline proteinuria, smoking, and number of comorbidities.

  • Ref, reference group homozygous for the major allele; NA, not applicable.

  • a Unadjusted for multiple comparisons.

  • b Statistical significance at an α=0.0045 after Bonferroni correction for 11 genotypes.