Table 1.

Baseline characteristics of AASK participants

Characteristics(n = 642)
Age (yr; mean ± SD)54 ± 10.5
Gender (females)41%
Serum creatinine [mg/dl; median (IQR)]1.8 (1.5, 2.3)
Mean baseline GFR47 ± 13.5
Systolic BP (mmHg; mean ± SD)150 ± 24
MAP BP (mmHg; mean ± SD)114 ± 16.1
Diastolic BP (mmHg; mean ± SD)96 ± 14
Urine protein/creatinine ratio (mean ± SD)0.31 ± 0.50
Mean urine 24-h proteinuria (mean ± SD)0.50 ± 0.94
Body mass index (mean ± SD)31.1 ± 6.7
Current smokers28% (n = 180)
CRP, [mg/dl; median (IQR)]0.5 (0.21, 0.93)
Incident ESRD12% (n = 80)
Number of patients halving the GFR17% (n = 109)
Death1.8% (n = 12)
Combined endpoint24% (n = 152)
Mean rate of decline ml/min per 1.73 m2−1.9 (−0.39, −3.5)
Blood pressure assignmentLow: 50.15% (n = 322); Usual: 49.9% (n = 320)
Drug assignment
ACE inhibitor41% (n = 265)
Low BP: 52%(n = 138)/Usual BP: 48%(n = 127)
β blocker39% (n = 252)
Low BP: 50%(n = 125)/Usual BP: 50%(n = 127)
Calcium channel blockers19% (n = 125)
Low BP: 47%(n = 59)/Usual BP: 53%(n = 66)