Table 4.

Hazard ratios for S100A12 (A) and sRAGE (B) levels with all-cause and CVD-related mortality in 184 hemodialysis patients

ModelCovariatesAll-Cause MortalityCVD Mortality
HR (95% CI)PHR (95% CI)P
(A) S100A12
    1Crude (per log10 ng/ml)1.93 (1.18 to 3.15)0.0083.43 (1.54 to 7.41)0.002
    21 + age and sex2.02 (1.22 to 3.27)0.0053.34 (1.53 to 7.03)0.002
    32 + dialysis vintage, diabetes, and baseline CVD1.87 (1.12 to 3.13)0.013.03 (1.32 to 6.98)0.009
    43 + IL-6 (per pg/ml)1.67 (0.97 to 2.87)0.063.33 (1.39 to 7.86)0.006
(B) sRAGE
    1Crude (per log10 ng/ml)1.03 (0.44 to 2.37)0.941.34 (0.34 to 5.05)0.67
    21 + age and sex1.40 (0.58 to 3.34)0.452.11 (0.51 to 8.67)0.31
    32 + dialysis vintage, diabetes, and baseline CVD1.46 (0.62 to 3.41)0.382.02 (0.50 to 7.95)0.32
    43 + IL-6 (per pg/ml)1.67 (0.71 to 3.92)0.242.24 (0.55 to 9.04)0.26
  • Indicated are crude HRs or with various degrees of adjustment (models 2 to 4) for all-cause and CVD-related mortality according to S100A12 and sRAGE levels. Categories for age and dialysis vintage were calculated according to the median value of the group. To correct for possible overfitting of the model, a shrinkage factor with Firth correction was applied in (A).