Table 1.

General characteristics of hemodialysis patients and healthy controls and univariate associations with S100A12 and sRAGE in patients

VariablesHealthy Controls (n = 50)Hemodialysis Patients (n = 184)ρb
S100A12sRAGE
S100A12, ng/ml6.7 (4.6 to 10.0)d14.7 (8.8 to 32.5)a
sRAGE, ng/ml1.3 (0.8 to 1.7)3.9 (2.7 to 6.0)a−0.056
Age, years63 (58 to 70)67 (51 to 74)0.0070.042
Men, %31 (62%)f101 (55%)0.036−0.171*
Dialysis vintage, months29 (14 to 55)−0.150*0.111
Diabetes mellitus, %0 (0%)45 (24%)a0.033−0.017
Clinical CVD, %0 (0%)118 (64%)a0.178*0.013
BMI, kg/m225.4 (±3.9)e24.8 (±5.3)0.041−0.259***
PEW,c %2 (4%)84 (46%)a0.149*0.038
s-Albumin, g/L39.0 (±2.8)35.0 (±4.2)a−0.1190.014
s-Creatinine, μmol/L79 (±15)786 (±207)a−0.056−0.126
Total cholesterol, mmol/L5.2 (±0.8)4.3 (±0.9)a0.0600.081
LDL cholesterol, mmol/L3.3 (±0.8)2.6 (±0.8)a0.0810.038
Calcium, mmol/L2.3 (±0.1)2.5 (±0.2)a0.0620.053
Phosphate, mmol/L1.0 (±0.2)1.9 (±0.6)a0.078−0.041
White blood cell count, 109/L6.1 (±1.9)8.0 (±2.5)a0.376***0.026
CRP, mg/L1.2 (0.6 to 2.6)6.4 (2.5 to 19.5)a0.426***−0.198**
IL-6, pg/ml1.4 (1.0 to 2.7)8.5 (4.8 to 15.0)a0.391***−0.065
  • a Significantly different (P < 0.05) from healthy individuals as assessed by Mann-Whitney U or χ2 test.

  • b Univariate correlations as assessed by Spearman's rank correlation analysis. Asterisks denote statistical significance: *P < 0.05; **P < 0.01; ***P < 0.001.

  • c Defined as subjective global assessment >1.

  • d Median value; 25th to 75th percentile shown in parentheses (all such values).

  • e Mean ± SD (all such values).

  • f Prevalence, shown in number and percentage (all such values).