Table 1.

Baseline clinical and histologic characteristics of patients with SRNS or SDNS

CharacteristicSRNSa (n = 33)SDNS (n = 24)
Age at onset (years)6.3 ± 4.8 (1 to 41)2.8 ± 0.9 (1 to 5)
Age at rituximab therapy (years)12.7 ± 9.1 (2 to 41)11.7 ± 2.9 (5 to 17)
Boys1719
Type of resistance (initial/late)24/9
Renal histologyn = 33n = 16
    MCD1712
    FSGS162
    mesangial hypercellularity2
Previous immunosuppressive therapy3324
    long-term alternate day prednisolone3324
    intravenous methylprednisolone92
    levamisole216
    mycophenolate mofetil315
    cyclophosphamide20 (23 courses)22 (24 courses)
    calcineurin inhibitor2415
    vincristine20
Duration of CNI therapy (months)22.7 ± 17.1 (4 to 56)20.7 ± 10.2 (8 to 36)
CNI toxicity115
Cushingoid features224
Cataract08
  • Data shown as mean ± SD (range). CNI, calcineurin inhibitor.

  • a Includes three adult patients, 35, 36, and 41 years old, with initial steroid resistance.