Table 1.

Characteristics of patients with and without PAD

AllPAD (−)PAD (+)Pa
N31524075
Age (years)b60.6 ± 12.7 (28 to 90)59.0 ± 12.9 (28 to 89)66.1 ± 10.2 (44 to 90)<0.0001
Percent female32.735.822.70.0352
HD vintage (years)b9.0 ± 7.9 (0.3 to 22.2)9.3 ± 8.0 (0.3 to 22.2)8.1 ± 7.6 (0.3 to 19.7)0.2384
Diabetes (%)31.122.259.5<0.0001
Current smoking (%)41.13562.7<0.0001
Hemoglobin (g/dl)c10.3 ± 0.9 (10.21 to 10.43)10.3 ± 0.9 (10.18 to 10.42)10.4 ± 1.0 (10.16 to 10.61)0.5215
Albumin (g/dl)c3.9 ± 0.4 (3.84 to 3.92)3.9 ± 0.4 (3.86 to 3.95)3.8 ± 0.3 (3.73 to 3.90)0.0577
Kt/Vc1.45 ± 0.26 (1.418 to 1.481)1.48 ± 0.27 (1.440 to 1.515)1.36 ± 0.21 (1.312 to 1.414)0.0019
Tcho (mg/dl)c142.5 ± 33.1 (138.75 to 146.28)139.7 ± 34.1 (135.29 to 144.15)152.0 ± 27.6 (145.30 to 158.64)0.0071
HDL cholesterol (mg/dl)c45.3 ± 13.7 (43.70 to 46.99)46.3 ± 14.2 (44.29 to 48.24)42.6 ± 12.0 (39.74 to 45.53)0.0593
LDL cholesterol (mg/dl)c79.2 ± 22.2 (76.55 to 81.81)78.0 ± 22.6 (74.90 to 81.06)82.9 ± 20.9 (77.83 to 87.93)0.1145
Triglyceride (mg/dl)c114.3 ± 85.2 (104.21 to 124.36)108.4 ± 82.8 (97.14 to 119.71)132.3 ± 90.4 (110.41 to 154.18)0.0445
iPTH (pg/ml)c234.9 ± 215.1 (209.99 to 259.89)238.1 ± 222.0 (208.56 to 267.68)224.9 ± 192.8 (178.53 to 271.18)0.6559
Adjusted Ca (mg/dl)c8.8 ± 0.7 (8.75 to 8.91)8.9 ± 0.7 (8.77 to 8.95)8.7 ± 0.7 (8.56 to 8.88)0.1376
P (mg/dl)c5.7 ± 1.2 (5.57 to 5.84)5.7 ± 1.1 (5.55 to 5.86)5.7 ± 1.3 (5.42 to 6.02)0.9047
Ca x P (mg2/dl2)c50.4 ± 10.9 (49.09 to 51.62)50.5 ± 10.8 (49.09 to 51.97)49.8 ± 11.3 (47.10 to 52.53)0.6385
Total ALP (U/L)c270.4 ± 119.2 (256.55 to 284.21)270.7 ± 120.4 (254.66 to 286.73)269.4 ± 116.26 (241.45 to 297.30)0.9364
baPWV (cm/s)c1914.8 ± 639.4 (1840.1 to 1989.5)1846.8 ± 590.8 (1761.6 to 1931.9)21115.3 ± 733.1 (1969.2 to 2261.4)0.0020
Comorbidities (%)
    hypertension79.076.786.70.0738
    stroke20.615.936.00.0005
    CAD20.312.545.3<0.0001
Medication
    CaCO3 (g/day)b1.6 ± 0.9 (0.0 to 4.5)1.6 ± 0.9 (0.0 to 3.5)1.8 ± 0.9 (0.0 to 4.5)0.1042
    sevelamer hydrochloride (mg/day)b1469 ± 1405 (0 to 7500)1364 ± 1286 (0 to 7500)1757 ± 1666 (0 to 7500)0.1098
    ACE-I/ARB (%)33.732.537.30.4845
    statin (%)21.320.424.00.5201
    aspirin (%)69.869.272.00.6686
    clostazol (%)5.12.912.00.0042
    ticlopidine (%)12.47.129.3<0.0001
    prostaglandin E (%)5.42.116.0<0.0001
  • HD, hemodialysis; Tcho, total cholesterol; iPTH, intact parathyroid hormone; P, phosphate; Ca, calcium; ALP, alkaline phosphatase; ACE-I, angitensin converting enzyme inhibitor; ARB, angiotensin receptor blocker.

  • a PAD (−) verus PAD (+).

  • b Mean ± SD (range).

  • c Mean ± SD (95% confidence interval).