Table 4.

Main hematologic parameters in 20 patients with RTX administration—baseline to 24 months

ParameterReference RangeBaselineMonth 3Month 6Month 12Month 18Month 24
Hemoglobin (g/100 ml)13.5 to 17.5 (g/dl)12.8 ± 1.712.5 ± 1.612.4 ± 1.513.1 ± 1.413.4 ± 1.513.3 ± 1.7
White blood cell count (×103 μl−1)3.5 to 10.5 (×103 μl−1)7.3 ± 1.27.1 ± 2.06.9 ± 1.86.8 ± 1.46.9 ± 1.96.3 ± 1.7
Lymphocytes (×103 μl−1)0.9 to 2.9 (×103 μl−1)2.0 ± 0.81.7 ± 0.6a1.7 ± 0.7a1.7 ± 0.5a1.8 ± 0.51.9 ± 0.6
Serum IgG total (mg/dl)600 to 1500 (mg/dl)426 ± 165521 ± 201a561 ± 218a652 ± 251a699 ± 299671 ± 262a
Serum IgG subclass (mg/dl)
    IgG1490 to 1140 (mg/dl)266 ± 124309 ± 142a340 ± 161a409 ± 163a
    IgG2150 to 640 (mg/dl)115 ± 42141 ± 62149 ± 55a176 ± 58a
    IgG320 to 110 (mg/dl)25 ± 1230 ± 1831 ± 2033 ± 18a
    IgG48 to 140 (mg/dl)33 ± 2829 ± 2227 ± 1930 ± 33
Serum IgM (mg/dl)50 to 300 (mg/dl)76 ± 4563 ± 43a56 ± 36a46 ± 30a44 ± 28a45 ± 23a
Serum IgA (mg/dl)50 to 400 (mg/dl)184 ± 82195 ± 90185 ± 75181 ± 75202 ± 102166 ± 65
  • Data are presented as mean ± SD. Ig, immunoglobulin.

  • a P ≤ 0.05 versus month 0.