Table 4.

Biomarker performance at the time of clinical serum creatinine increase

Stage 1 or 2a (n = 37)Stage 3a (n = 9)AUC (95% confidence interval)P
Plasma creatinine
    absolute change (mg/dl)0.360 (0.30 to 0.58)0.396 (0.28 to 0.52)0.68 (0.42 to 0.94)NS
    % change from baseline39.6 (28 to 52)50.0 (24 to 114)0.60 (0.33 to 0.87)NS
CyC
    absolute (mg/L)0.114 (0.027 to 0.23)0.272 (0.22 to 0.72)0.74 (0.53 to 0.96)0.02
    normalizedb (mg/g)0.101 (0.040 to 0.32)0.725 (0.51 to 1.17)0.77 (0.55 to 0.98)0.01
NGAL
    absolute (pg/ml)98.3 (17.0 to 324)461 (231 to 2047)0.78 (0.61 to 0.96)0.02
    normalizedb (ng/mg)79.7 (14.6 to 37.6)571 (332 to 6273)0.78 (0.59 to 0.98)0.01
KIM-1
    absolute (pg/ml)672.9 (407 to 2492)743.4 (576 to 939)0.49 (0.29 to 0.69)NS
    normalizedb (ng/mg)0.987 (0.480 to 1.74)1.59 (1.02 to 1.83)0.65 (0.45 to 0.86)NS
HGF
    absolute (pg/ml)164.3 (56.2 to 524.5)209.8 (123.7 to 1344)0.66 (0.45 to 0.86)NS
    normalizedb (ng/mg)0.148 (0.062 to 0.763)0.601 (0.161 to 3.675)0.68 (0.47 to 0.89)NS
α-GST
    absolute (μg/L)1.29 (0.79 to 2.82)2.18 (0.38 to 20.9)0.54 (0.25 to 0.84)NS
    normalizedb (ng/mg)1.45 (0.89 to 4.41)2.93 (0.33 to 88.5)0.54 (0.26 to 0.82)NS
π-GST
    absolute (μg/L)3.4 (3.4 to 10.9)46.5 (13.5 to 286.3)0.84 (0.69 to 0.99)0.003
    normalizedb (ng/mg)3.69 (2.35 to 11.5)54.8 (17.0 to 1175.2)0.86 (0.74 to 0.99)0.002
FENa (%)0.312 (0.010 to 0.869)2.12 (0.23 to 2.395)0.67 (0.47 to 0.87)NS
FEUrea (%)34.5 (14.7 to 38.4)33.4 (19.2 to 60.8)0.51 (0.25 to 0.77)NS
  • a Values presented as median (IQR).

  • b Urine excretion normalized to urinary creatinine concentration.