Table 3.

Biomarker performance for stage 3 AKI—entire cohort and stratified by eGFR

Stage 3 AKIEntire Cohort (n = 123)eGFR <60 ml/min (n = 49)eGFR >60 ml/min (n = 74)
CyC (mg/L)
    baseline0.41 (0.16 to 0.66)0.44 (0.09 to 0.80)0.40 (0.16 to 0.85)
    ICU arrival0.84 (0.68 to 0.99)b0.74 (0.43 to 0.98)0.93 (0.84 to 0.99)a
    6-hour ICU0.78 (0.85 to 0.99)a0.51 (0.04 to 0.98)0.98 (0.94 to 0.99)a
    early max0.85 (0.69 to 0.99)b0.81 (0.52 to 0.98)a0.93 (0.83 to 0.99)a
CyC (mg/g)
    baseline0.35 (0.09 to 0.61)0.43 (0.06 to 0.80)0.45 (0.30 to 0.83)
    ICU arrival0.82 (0.67 to 0.97)a0.69 (0.40 to 0.98)0.93 (0.86 to 0.99)a
    6-hour ICU0.77 (0.52 to 0.99)a0.47 (0.01 to 092)0.98 (0.96 to 0.99)a
    early max0.85 (0.71 to 0.98)b0.77 (0.50 to 0.98)a0.91 (0.82 to 0.99)a
NGAL (pg/ml)
    baseline0.73 (0.56 to 0.89)a0.81 (0.59 to 0.98)a0.59 (0.42 to 0.75)
    ICU arrival0.79 (0.65 to 0.94)a0.68 (0.41 to 0.94)0.92 (0.78 to 0.98)a
    6-hour ICU0.88 (0.73 to 0.99)b0.73 (0.34 to 0.97)0.97 (0.90 to 0.99)a
    early max0.82 (0.66 to 0.97)a0.73 (0.44 to 0.97)0.92 (0.75 to 0.98)a
NGAL (ng/mg)
    baseline0.71 (0.51 to 0.91)a0.85 (0.67 to 0.99)a0.48 (0.26 to 0.70)
    ICU arrival0.80 (−0.66 to 0.94)a0.65 (0.41 to 0.89)0.92 (0.77 to 0.99)a
    6-hour ICU0.88 (0.73 to 0.99)b0.69 (0.30 to 0.90)0.98 (0.92 to 0.99)a
    early max0.82 (0.66 to 0.98)a071 (0.41 to 0.95)0.92 (0.74 to 0.99)a
KIM-1 (pg/ml)
    baseline0.82 (0.68 to 0.95)a0.82 (0.65 to 0.99)a0.80 (0.53 to 0.99)a
    ICU arrival0.69 (0.44 to 0.93)0.69 (0.17 to 0.90)0.70 (0.37 to 0.90)
    6-hour ICU0.45 (0.17 to 0.73)0.52 (0.15 to 0.85)0.47 (0.14 to 0.81)
    early max0.58 (0.37 to 0.79)0.65 (0.36 to 0.94)0.48 (0.14 to 0.82)
KIM-1 (ng/mg)
    baseline0.76 (0.57 to 0.94)a0.77 (0.52 to 0.98)a0.67 (0.52 to 0.83)a
    ICU arrival0.68 (0.38 to 0.97)0.65 (0.20 to 0.87)0.73 (0.36 to 0.95)
    6-hour ICU0.54 (0.27 to 0.82)0.55 (0.19 to 0.87)0.67 (0.42 to 0.92)
    early max0.72 (0.51 to 0.93)a0.80 (0.49 to 0.98)0.55 (0.37 to 0.91)
HGF (pg/ml)
    baseline0.44 (0.23 to 0.65)0.51 (0.24 to 0.76)0.23 (0.04 to 0.44)a
    ICU arrival0.57 (0.35 to 0.78)0.46 (0.22 to 0.71)0.65 (0.25 to 0.98)
    6-hour ICU0.65 (0.45 to 0.86)0.44 (0.22 to 0.85)0.73 (0.50 to 0.98)a
    early max0.54 (0.35 to 0.74)0.40 (0.21 to 0.60)0.65 (0.30 to 0.95)
HGF (ng/mg)
    baseline0.43 (0.17 to 0.63)0.51 (0.16 to 0.85)0.16 (0.02 to 0.38)a
    ICU arrival0.64 (0.38 to 0.89)0.57 (0.21 to 0.92)0.68 (0.25 to 0.98)
    6-hour ICU0.67 (0.45 to 0.90)0.52 (0.12 to 0.95)0.84 (0.67 to 0.98)a
    early max0.67 (0.45 to 0.88)0.60 (0.32 to 0.87)0.69 (0.30 to 0.99)
α-GST (μg/L)
    baseline0.23 (0.01 to 0.37)a0.29 (0.08 to 0.50)a0.19 (0.07 to 0.30)a
    ICU arrival0.58 (0.31 to 0.85)0.41 (0.07 to 0.76)0.77 (0.35 to 0.99)
    6-hour ICU0.68 (0.35 to 0.99)0.61 (0.07 to 0.99)0.75 (0.27 to 0.95)
    early max0.58 (0.30 to 0.87)0. 46 (0.10 to 0.82)0.74 (0.27 to 0.99)
α-GST (ng/mg)
    baseline0.24 (0.06 to 0.42)a0.30 (0.03 to 0.58)0.13 (0.03 to 0.23)a
    ICU arrival0.60 (0.33 to 0.86)0.44 (0.09 to 0.80)0.77 (0.35 to 0.98)
    6-hour ICU0.67 (0.35 to 0.99)0.53 (0.03 to 0.98)0.77 (0.32 to 0.99)
    early max0.63 (0.38 to 0.88)0.51 (0.18 to 0.83)0.76 (0.33 to 0.98)
π-GST (μg/L)
    baseline0.53 (0.32 to 0.73)0.53 (0.27 to 0.78)0.51 (0.17 to 0.85)
    ICU arrival0.70 (0.50 to 0.90)a0.61 (0.34 to 0.89)0.81 (0.50 to 0.99)a
    6-hour ICU0.78 (0.56 to 0.99)a0.56 (0.18 to 0.93)0.93 (0.79 to 0.99)a
    early max0.72 (0.51 to 0.93)a0.54 (0.22 to 0.86)0.92 (0.82 to 0.99)a
π-GST (ng/mg)
    baseline0.43 (0.20 to 0.66)0.43 (0.09 to 0.77)0.37 (0.10 to 0.73)
    ICU arrival0.69 (0.47 to 0.92)0.59 (0.27 to 0.91)0.81 (0.50 to 0.98)a
    6-hour ICU0.76 (0.54 to 0.99)a0.46 (0.06 to 0.86)0.93 (0.80 to 0.98)a
    early max0.74 (0.54 to 0.94)a0.58 (0.28 to 0.89)0.91 (0.83 to 0.99)a
FENa (%)
    baseline0.63 (0.46 to 0.76)0.61 (0.37 to 0.84)0.52 (0.38 to 0.67)
    ICU arrival0.56 (0.41 to 0.70)0.53 (0.24 to 0.83)0.59 (0.45 to 0.73)
    6-hour ICU0.62 (0.39 to 0.84)0.29 (0.02 to 0.65)0.84 (0.71 to 0.97)a
    early max0.65 (0.51 to 0.79)0.63 (0.38 to 0.89)0.66 (0.49 to 0.82)
    early min0.64 (0.45 to 0.83)0.50 (0.15 to 0.86)0.81 (0.68 to 0.92)a
FEUrea (%)
    baseline0.38 (0.17 to 0.59)0.51 (0.30 to 0.71)0.39 (0.12 to 0.65)
    ICU arrival0.47 (0.25 to 0.69)0.36 (0.18 to 0.54)0.47 (0.16 to 0.83)
    6-hour ICU0.53 (0.28 to 0.77)0.45 (0.24 to 0.66)0.56 (0.21 to 0.90)
    early max0.57 (0.36 to 0.74)0.35 (0.18 to 0.52)0.60 (0.39 to 0.82)