Table 4.

Cox regression: Hazard ratios across international targets of serum phosphate for CKD stages 3 to 5

UK Renal AssociationKDOQI
All-Cause MortalityCV MortalityAll-Cause MortalityCV Mortality
HR (95% CI)PHR (95% CI)PHR (95% CI)PHR (95% CI)P
Below target1.01.01.01.0
In target1.7 (1.0, 2.8)0.051.6 (0.8, 3.5)0.21.8 (0.98, 3.8)0.061.8 (0.7, 4.6)0.2
Above target2.8 (1.5, 5.4)0.0024.1 (1.5, 10.6)0.0042.7 (1.3, 5.7)0.0094.0 (1.4, 11.9)0.01
  • UKRA target range: CKD stages 3 to 4: 0.9 to 1.5 mmol/L; CKD stage 5: 1.1 to 1.8 mmol/L. KDOQI target range: CKD stages 3 to 4: 0.87 to 1.48 mmol/L; CKD stage 5: 1.13 to 1.78 mmol/L. Analysis adjusted for age, gender, proteinuria, diabetes, hemoglobin, systolic blood pressure, current smoking status, cardiovascular disease, eGFR, and vitamin D analog and phosphate binder use.