Table 2.

Cox regression: Hazard ratios across quartiles of phosphate relative to eGFR in patients with CKD stages 3 to 4

N = 1036, Phosphate Quartiles According to eGFRAll-Cause MortalityCardiovascular Mortality
HR (95% CI)PHR (95% CI)P
First quartile (low)1.01.0
Second quartile1.6 (1.00, 2.4)0.051.8 (0.9, 3.7)0.1
Third quartile1.6 (0.99, 2.5)0.062.8 (1.3, 5.9)0.007
Fourth quartile (high)1.8 (1.1, 3.1)0.022.9 (1.3, 6.4)0.01
  • Analysis adjusted for age, gender, proteinuria, diabetes, hemoglobin, systolic blood pressure, current smoking status, cardiovascular disease, eGFR, renal replacement therapy, and vitamin D analog and phosphate binder use.