Table 1.

Demographic data across quartiles of phosphate adjusted for eGFR

N = 1203, Mean (SD), n (%), Median (range)AllFirst Quartile, n = 275Second Quartile, n = 345Third Quartile, n = 320Fourth Quartile, n = 263P
Age (years)64 (14)66 (13)65 (14)64 (13)61 (15)<0.0005
Female gender427 (36%)74 (27%)114 (33%)126 (40%)113 (43%)<0.0005
eGFR (ml/min per 1.73 m2)32 (15)32 (15)32 (15)31 (15)33 (16)0.561
Corr. calcium (mmol/L)2.29 (0.14)2.28 (0.13)2.30 (0.15)2.28 (0.14)2.30 (0.15)0.119
Phosphate (mmol/L)1.2 (0.31) (0.45 to 3.47)0.9 (0.17) (0.45 to 1.38)1.1 (0.16) (0.83 to 1.67)1.3 (0.20) (0.99 to 1.98)1.5 (0.32) (1.08 to 3.47)<0.0001
PTH (pg/ml) normal range 10 to 6589 (1 to 1019)87 (4 to 677)88 (2 to 699)95 (3 to 1019)87 (1 to 488)0.683
Hemoglobin (g/L)124 (17)130 (17)125 (18)122 (15)120 (17)<0.0005
Proteinuria (grams per day)1.1 (0 to 16.2)0.8 (0.05 to 8.9)0.8 (0.05 to 14.9)1.3 (0.1 to 16.2)1.5 (0 to 15.1)<0.0005
CVD379 (32%)93 (34%)119 (35%)105 (33%)62 (23%)0.015
DM383 (32%)80 (29%)93 (27%)118 (37%)92 (35%)0.022
SBP (mmHg)139 (22)141 (21)138 (21)140 (22)138 (24)0.338
DBP (mmHg)76 (13)76 (13)76 (12)77 (13)76 (13)0.771
PP63 (19)65 (19)62 (18)64 (19)63 (22)0.279
Weight (kg)81 (18)85 (20)82 (17)79 (19)77 (17)<0.0005
BMI28 (6)29 (7)29 (5)28 (6)27 (6)0.003
Current smoker156 (13%)18 (7%)37 (11%)52 (16%)49 (19%)<0.0005
Ever smoked832 (69%)190 (69%)242 (70%)209 (66%)191 (72%)0.363
All binders90 (8%)16 (6%)17 (5%)24 (8%)33 (13%)0.003
Non-Ca phosphate binders11 (1%)2 (0.7%)1 (0.3%)4 (1.3%)4 (1.5%)0.387
Calcium-containing phosphate binders81 (7%)15 (6%)16 (5%)20 (6%)30 (12%)0.007
Vitamin D analogs199 (17%)47 (17%)63 (18%)52 (16%)37 (14%)0.607
  • PTH, parathyroid hormone; CaxP, calcium × phosphate product; CVD, cardiovascular disease; DM, diabetes; SBP, systolic blood pressure; DBP, diastolic blood pressure; PP, pulse pressure; BMI, body mass index; Non-Ca, non–calcium containing.