Table 3.

Clinical characteristics of Fabry registry patients grouped by baseline eGFR values

eGFRP
≥90<90 to ≥60<60
Men
    number of male patients, N683617
    eGFRa at baseline, mean SD)109 (13.3)78 (8.6)42 (13.7)
    age at baseline eGFR, mean (SD), years30 (9.4)37 (12.5)47 (16.1)<0.0001
    men with baseline UP/Cr data, n29127
        UP/Cr, baseline mean (SD)0.9 (1.0)1.5 (1.4)1.8 (1.3)NS
        median (25th, 75th)0.6 (0.2, 1.1)1.3 (0.6, 1.8)1.5 (0.8, 3.5)
    men with averaged UP/Cr data, n683617
        UP/Cr, averaged mean (SD)0.8 (0.7)1.3 (1.3)1.9 (1.6)0.0025
        median (25th, 75th)0.6 (0.2, 1.2)0.9 (0.1, 1.9)1.5 (1.1, 2.2)
    BP, n633411
        averaged systolic BP (median, 25th, 75th), mmHg128 (120, 137)126 (114, 132)122 (118, 134)NS
        averaged diastolic BP (median, 25th, 75th), mmHg77 (72, 84)77 (72, 82)72 (70, 78)NS
    reported history of ACEi/ARB use, n (%)12 (18)9 (25)5 (29)NS
Women
    number of female patients, N21011417
    eGFRa at baseline, mean (SD)109 (11.6)76 (8.0)47 (8.8)
    age at baseline eGFR, mean (SD), years35 (11.3)46 (10.7)59 (11.7)<0.001
    women with baseline UP/Cr data, n1095910
        UP/Cr, baseline mean (SD)0.7 (0.9)0.8 (1.1)2.5 (2.1)0.004
        median (25th, 75th)0.2 (0.1, 0.9)0.5 (0.1, 1.0)2.1 (0.5, 4.2)
    women with averaged UP/Cr data, n21011417
        UP/Cr, averaged mean (SD)0.7 (0.9)1.0 (1.4)1.8 (1.9)0.002
        median (25th, 75th)0.2 (0.1, 0.9)0.4 (0.1, 1.4)1.0 (0.3, 2.9)
    BP, n19611016
        averaged systolic BP (median, 25th, 75th), mmHg119 (111, 129)125 (113, 135)138 (131, 144)<0.0001
        averaged diastolic BP (median, 25th, 75th), mmHg74 (68, 80)77 (70, 83)84 (74, 90)0.003
    reported history of ACEi/ARB use, n (%)34 (16)21 (18)9 (53)0.008
  • “Averaged” data reflect the average of all values reported within 6 months of the date of the first eGFR assessment to the most recent assessment. P values were calculated by the Kruskal-Wallis test; NS, not significant.

  • a eGFR data are expressed as ml/min per 1.73 m2.