Table 5.

Maternal events analysis

EventDenominatorFixed-Effects AnalysisRandom-Effects Analysis
Test for HeterogeneityEstimated Rate (95% CI)Estimated Rate (95% CI)SD Estimatea
Maternal deathbNo. of Pregnancies<0.0012.1% (1.3%, 3.0%)1.0% (0.0%, 2.0%)1.3%
StrokebNo. of Pregnancies1.000.8% (0.0%, 1.5%)
HypertensionNo. of Pregnancies<0.00115.3% (13.3%, 17.3%)16.3% (10.3%, 22.3%)11.2%
Pre-eclampsiaNo. of Pregnancies<0.0019.1% (7.4%, 10.8%)7.6% (3.6%, 11.6%)7.6%
EclampsiaNo. of Pregnancies0.1840.8% (0.0%, 1.6%)
Active nephritisNo. of Pregnancies<0.00119.0% (17.4%, 20.6%)16.1% (9.0%, 23.2%)18.9%
FlaresNo. of Pregnancies<0.00129.2% (27.3%, 31.0%)25.6% (17.4%, 33.8%)22.8%
  • a To compute an estimate of the random-effects SD, which depends on the value of the complication rate, the central value from the random-effects model (i.e., the random-effects estimated rate) was used in the calculation.

  • b Random-effects estimates were not computed for maternal death or stroke because neither of the event rates showed study heterogeneity.