Event | Denominator | Fixed-Effects Analysis | Random-Effects Analysis | ||
---|---|---|---|---|---|

Test for Heterogeneity | Estimated Rate (95% CI) | Estimated Rate (95% CI) | SD Estimate^{a} | ||

Maternal death^{b} | No. of Pregnancies | <0.001 | 2.1% (1.3%, 3.0%) | 1.0% (0.0%, 2.0%) | 1.3% |

Stroke^{b} | No. of Pregnancies | 1.00 | 0.8% (0.0%, 1.5%) | — | — |

Hypertension | No. of Pregnancies | <0.001 | 15.3% (13.3%, 17.3%) | 16.3% (10.3%, 22.3%) | 11.2% |

Pre-eclampsia | No. of Pregnancies | <0.001 | 9.1% (7.4%, 10.8%) | 7.6% (3.6%, 11.6%) | 7.6% |

Eclampsia | No. of Pregnancies | 0.184 | 0.8% (0.0%, 1.6%) | — | — |

Active nephritis | No. of Pregnancies | <0.001 | 19.0% (17.4%, 20.6%) | 16.1% (9.0%, 23.2%) | 18.9% |

Flares | No. of Pregnancies | <0.001 | 29.2% (27.3%, 31.0%) | 25.6% (17.4%, 33.8%) | 22.8% |

↵a To compute an estimate of the random-effects SD, which depends on the value of the complication rate, the central value from the random-effects model (i.e., the random-effects estimated rate) was used in the calculation.

↵b Random-effects estimates were not computed for maternal death or stroke because neither of the event rates showed study heterogeneity.