Table 3.

Adjusted hazard ratios of eGFR for CV outcomes for subjects younger and older than 60 years of age

eGFR byModel 1: CrudeModel 2: + GenderModel 3: + ln UAEModel 4: + CV Risk Factors
HRCIHRCIHRCIHRCI
Age <60 years
    MDRD (+10 ml/min per 1.73 m2)0.760.67 to 0.860.660.58 to 0.750.680.60 to 0.780.710.63 to 0.81
    CKD EPI (+10 ml/min per 1.73 m2)0.700.62 to 0.790.650.58 to 0.730.670.60 to 0.750.700.62 to 0.79
    CysC (+10 ml/min per 1.73 m2)0.800.75 to 0.860.800.75 to 0.850.810.76 to 0.860.860.79 to 0.92
    Combi (+10 ml/min per 1.73 m2)0.690.62 to 0.760.660.60 to 0.730.680.61 to 0.750.740.66 to 0.82
    Creatinine clearance (+10 ml/min per 1.73 m2)0.860.78 to 0.950.820.75 to 0.910.800.73 to 0.890.930.87 to 1.00
Age ≥60 years
    MDRD (+10 ml/min per 1.73 m2)1.080.98 to 1.191.000.91 to 1.111.030.93 to 1.131.030.94 to 1.14
    CKD EPI (+10 ml/min per 1.73 m2)1.030.93 to 1.140.970.88 to 1.081.030.93 to 1.131.020.92 to 1.13
    CysC (+10 ml/min per 1.73 m2)0.930.87 to 0.990.920.86 to 0.980.940.88 to 1.000.970.91 to 1.04
    Combi (+10 ml/min per 1.73 m2)0.960.88 to 1.050.920.85 to 1.010.950.87 to 1.040.990.90 to 1.08
    Creatinine clearance (+10 ml/min per 1.73 m2)0.920.85 to 0.990.880.81 to 0.950.880.82 to 0.950.940.88 to 0.99
  • CV risk factors: body mass index, systolic BP, total cholesterol (mmol/L), fasting glucose (mmol/L), smoking status, history of CV disease.