Table 2.

Hazard ratio of eGFR for CV outcomes in continuous models

eGFR byModel 1: CrudeModel 2: + Age + GenderModel 3: + ln UAEModel 4: + CV Risk FactorsInteraction Term: Age × eGFR
HRCIHRCIHRCIHRCIHRP
MDRD (per 10 ml/min per 1.73 m2)0.760.71 to 0.820.930.86 to 1.010.960.88 to 1.030.950.88 to 1.021.01<0.001
CKD EPI (per 10 ml/min per 1.73 m2)0.680.64 to 0.730.920.85 to 1.000.940.87 to 1.020.940.87 to 1.021.02<0.001
CysC (per 10 ml/min per 1.73 m2)0.770.74 to 0.800.900.86 to 0.950.910.87 to 0.960.950.90 to 0.991.010.002
Combi (per 10 ml/min per 1.73 m2)0.690.64 to 0.730.870.82 to 0.940.900.84 to 0.960.930.86 to 0.991.01<0.001
Creatinine clearance (per 10 ml/min per 1.73 m2)0.860.82 to 0.900.940.90 to 0.980.940.89 to 0.980.950.91 to 0.991.010.40
  • CV risk factors: body mass index, systolic BP, total cholesterol (mmol/L), fasting glucose (mmol/L), smoking status, history of CV disease.