Table 3.

Effect of timing of dialysis start on patient survival using Cox models in the entire study population and patient subgroupsa

HR (95% CI)P
Entire study population (n = 895,293)b
    eGFR >15 ml/min per 1.73 m21.44 (1.43 to 1.45)<0.001
    eGFR >10 to 15 ml/min per 1.73 m21.15 (1.15 to 1.16)<0.001
    eGFR >5 to 10 ml/min per 1.73 m2Reference
    eGFR ≤5 ml/min per 1.73 m20.88 (0.87 to 0.88)<0.001
Age categoriesb
    Patients younger than 75 yr (n = 651,304)
        eGFR >15 ml/min per 1.73 m21.48 (1.46 to 1.49)<0.001
        eGFR >10 to 15 ml/min per 1.73 m21.17 (1.16 to 1.17)<0.001
        eGFR >5 to 10 ml/min per 1.73 m2Reference
        eGFR ≤5 ml/min per 1.73 m20.86 (0.85 to 0.86)<0.001
Patients 75 or older (n = 243,989)
        eGFR >15 ml/min per 1.73 m21.35 (1.33 to 1.37)<0.001
        eGFR >10 to 15 ml/min per 1.73 m21.11 (1.10 to 1.26)<0.001
        eGFR >5 to 10 ml/min per 1.73 m2Reference
        eGFR ≤5 ml/min per 1.73 m20.96 (0.94 to 0.97)<0.001
Dialysis modalityb
    Patients treated with peritoneal dialysis (n = 63,691)
        eGFR >15 ml/min per 1.73 m21.42 (1.37 to 1.47)<0.001
        eGFR >10 to 15 ml/min per 1.73 m21.10 (1.07 to 1.12)<0.001
        eGFR >5 to 10 ml/min per 1.73 m2Reference
        eGFR ≤5 ml/min per 1.73 m20.96 (0.93 to 0.99)0.02
    Patients treated with hemodialysis (n = 801,685)
        eGFR >15 ml/min per 1.73 m21.49 (1.47 to 1.50)<0.001
        eGFR >10 to 15 ml/min per 1.73 m21.17 (1.16 to 1.17)<0.001
        eGFR >5 to 10 ml/min per 1.73 m2Reference
        eGFR ≤5 ml/min per 1.73 m20.87 (0.86 to 0.87)<0.001
Comorbidity categoriesb
    Charlson comorbidity index <6 (n = 204,208)
        eGFR >15 ml/min per 1.73 m21.46 (1.42 to 1.5)<0.001
        eGFR >10 to 15 ml/min per 1.73 m21.18 (1.16 to 1.21)<0.001
        eGFR >5 to 10 ml/min per 1.73 m2Reference
        eGFR ≤5 ml/min per 1.73 m20.84 (0.83 to 0.85)<0.001
    Charlson comorbidity index 6 to 8 (n = 468,446)
        eGFR >15 ml/min per 1.73 m21.46 (1.44 to 1.48)<0.001
        eGFR >10 to 15 ml/min per 1.73 m21.15 (1.14 to 1.16)<0.001
        eGFR >5 to 10 ml/min per 1.73 m2Reference
        eGFR ≤5 ml/min per 1.73 m20.90 (0.89 to 0.91)<0.001
    Charlson comorbidity index >8 (n = 222,639)
        eGFR >15 ml/min per 1.73 m21.37 (1.35 to 1.39)<0.001
        eGFR >10 to 15 ml/min per 1.73 m21.13 (1.11 to 1.14)<0.001
        eGFR >5 to 10 ml/min per 1.73 m2Reference
        eGFR ≤5 ml/min per 1.73 m20.94 (0.92 to 0.95)<0.001
  • a Only primary variables of interest are presented in the table. All models were adjusted for the following covariates: age at ESRD onset, height and weight at the time of ESRD onset, race, sex, diabetic status, Charlson comorbidity index, duration of pre-dialysis nephrology care, type of dialysis, type of vascular access, and cause of ESRD.

  • b The number of subjects may be less than the entire study population because of missing variables.