Table 5.

Interaction effects of two risk factors from high HbA1C, high GFR, high SBP, low TP, and female on determining GFR decliner in subjects with diabetes a

Determinant bOR (95% CI)P
High HbA1C + high GFR3.54 (2.14 to 5.85)0.000
High HbA1C + high SBP3.19 (1.88 to 5.40)0.000
High HbA1C + low TP3.12 (1.81 to 5.37)0.000
High HbA1C + female3.47 (1.89 to 6.37)0.000
High GFR + high SBP2.34 (1.38 to 3.97)0.002
High GFR + low TP2.33 (1.39 to 3.93)0.001
High GFR + female2.60 (1.45 to 4.67)0.001
High SBP + low TP2.19 (1.30 to 3.71)0.003
High SBP + female2.38 (1.30 to 4.34)0.005
Low TP + female2.42 (1.34 to 4.36)0.003
  • a The interaction effects of two risk factors were explored by the presence/absence of the two factors with a reference as having both absences, after adjustment for other variables listed in Table 4.

  • b High HbA1C, high GFR, high SBP, and low TP were defined as HbA1C ≥ 7.0, GFR ≥ 77.4 ml/min/1.73 m2, SBP ≥ 127 mmHg, and TP ≤ 7.1 g/dl according to the results in Table 4.