Table 3.

Results of multiple linear regression analysis to assess the significance of baseline variables on GFR slope in all subjects and those with and without diabetes a b

Characteristic GFR slope (%/yr) dAll Subjects n = 923Subjects with DiabetesSubjects without Diabetes (n = 194)
All Subjects with Diabetes (n = 729)HypertensionBaseline GFR (ml/min/1.73 m2)
With (n = 375)Without (n = 354)≥77.4 (n = 390)<77.4 (n = 339)
−2.19 (−4.72 to 0.52)−2.39 (−4.86 to 0.15)−2.81 (−5.88 to 0.11)−2.00 (−4.34 to 0.28)−2.70 (−5.27 to −0.73)−1.65 (−4.36 to 0.99)−1.02 (−4.28 to 1.37)
RC c (0.11)PRC (0.11)PRC (0.09)PRC (0.18)PRC (0.19)PRC (0.13)PRC (0.15)P
Baseline HbA1C, per %−0.8320.000−0.7910.000−0.7760.041−0.6910.001−0.9710.000−0.4370.224−0.4080.779
Baseline GFR, per 10 ml/min/1.73 m2−0.7120.000−0.7550.000−0.8250.000−0.7200.000−0.4870.025−0.9250.003−0.5560.059
Baseline SBP, per 10 mmHg0.4600.000−0.3860.009−0.4010.083−0.2470.235−0.2640.218−0.4320.048−0.6720.016
Baseline plasma TP, per g/dl1.1760.0000.9690.0040.6210.2251.4430.0012.0160.0000.2170.6232.2090.011
  • a Subjects with diabetes were subsequently analyzed according to the presence of hypertension and baseline values of GFR.

  • b The independent variables were baseline factors such as age; BMI; gender; HbA1C; SBP; RASI use; baseline GFR; serum concentrations of HDL, LDL, and TG; plasma TP; hemoglobin; and platelet.

  • c Regression coefficient (RC) means milliliters of change in GFR by units of change in the risk factors; parentheses indicate the R2 value.

  • d Median and interquartile range are given. GFR value of 77.4 ml/min/1.73 m2 was the median in all subjects.