Table 2.

Comparison of clinical variables between GFR decliners and nondecliners in subjects with and without diabetes a

VariableSubjects with DiabetesSubjects without Diabetes
Decliner (n = 222)Nondecliner (n = 507)PDecliner (n = 52)Nondecliner (n = 142)P
Age (yr)59 ± 1258 ± 110.705463 ± 1160 ± 120.0957
Male (%)139 (62.6)365 (72.0)0.014921 (40.4)58 (40.8)0.9999
BMI (kg/m2)26.0 ± 4.425.6 ± 4.00.279724.7 ± 3.824.8 ± 4.00.7998
ACR
    at baseline12.8 (8.2 to 19.4) c)11.1 (7.8 to 17.0) c)0.0115
    at end of follow-up11.2 (7.4 to 20.5) c)11.0 (7.2 to 18.7) c)0.4993
Microalbuminuria at end of follow-up (%)32 (14.4)70 (13.8)0.9190
Serum Cr (mg/dl)
    at baseline0.70 ± 0.180.77 ± 0.20<0.00010.70 ± 0.170.77 ± 0.270.0814
    at end of follow-up0.87 ± 0.280.78 ± 0.19<0.00010.83 ± 0.190.74 ± 0.200.0067
GFR (ml/min/1.73 m2) b
    at baseline81.9 (70.8 to 98.0)77.8 (67.8 to 88.5)0.001674.9 (66.3 to 81.8)71.2 (62.4 to 82.7)0.3887
    at end of follow-up66.8 (55.6 to 80.3)75.4 (65.5 to 85.3)<0.000162.8 (54.3 to 70.1)71.7 (63.8 to 84.2)<0.0001
    change (follow-up − baseline)−13.9 (−19.6 to −8.5)−2.3 (−6.8 to 1.8)<0.0001−10.0 (−15.6 to −6.5)0.5 (−3.9 to 5.0)<0.0001
GFR slope per year (ml/min/1.73 m2) b−5.06 (−7.67 to −3.18)−0.32 (−1.48 to 1.20)<0.0001−4.36 (−6.79 to −3.52)0.26 (−0.78 to 2.00)<0.0001
GFR slope (%/yr) b−6.13 (−9.32 to −4.07)−0.50 (−1.92 to 1.67)<0.0001−5.97 (−9.32 to −4.56)0.36 (−1.04 to 3.13)<0.0001
HbA1C (%)
    at baseline6.9 ± 1.26.5 ± 0.9<0.00015.2 ± 0.45.3 ± 0.30.4594
    at second follow-up c6.8 ± 1.06.6 ± 0.90.04385.3 ± 0.35.3 ± 0.30.4429
Hypertension (%)127 (57.2)248 (48.9)0.047648 (76.9)108 (76.1)0.9999
SBP (mmHg)
    at baseline126 ± 14124 ± 140.0537136 ± 18129 ± 160.0195
    at second follow-up c125 ± 17121 ± 140.0045126 ± 20125 ± 140.6167
DBP (mmHg)
    at baseline68 ± 1168 ± 100.913177 ± 1472 ± 120.0087
    at second follow-up c68 ± 1267 ± 110.602868 ± 1269 ± 100.4554
RASI use in patients with hypertension (%)
    at baseline96 (43.2)191 (37.7)0.182126 (50.0)71 (50.0)1.0000
    at second follow-up c110 (49.5)212 (41.8)0.063730 (57.7)76 (53.5)0.7233
Hyperlipidemia (%)142 (64.0)343 (67.7)0.375640 (76.9)108 (76.1)0.9999
HDL (mg/dl)54 ± 1453 ± 130.327957 ± 1559 ± 150.4021
LDL (mg/dl)108 ± 33110 ± 280.3809110 ± 34116 ± 320.2210
TG (mg/dl)158 ± 114158 ± 1280.9894186 ± 140152 ± 1080.0744
Plasma TP (g/dl)
    at baseline7.0 ± 0.77.1 ± 0.60.02487.2 ± 0.77.3 ± 0.40.0534
    at second follow-up c7.1 ± 0.47.1 ± 0.40.44367.1 ± 0.47.1 ± 0.40.4207
Hemoglobin (g/dl)14.0 ± 1.614.1 ± 1.50.262513.8 ± 1.713.6 ± 1.70.5928
Platelet (104/mm3)22.2 ± 6.022.6 ± 5.70.357623.7 ± 5.623.7 ± 5.30.9743
  • a See Patients and Methods for definition.

  • b Median and interquartile range are given.

  • c One year after baseline.