Eligibility and exclusion criteria
| Eligibility criteria |
| Age stratum (yr)/eligible eGFR range (ml/min per 1.73 m2)a |
| 21 to 44/20 to 70 |
| 45 to 64/20 to 60 |
| 65 to 74/20 to 50 |
| Exclusion criteria |
| institutionalized (e.g., prisoner, nursing home or skilled nursing facility resident) |
| unable or unwilling to give consent |
| unlikely or unable to participate in required study procedures |
| New York Heart Association class III or IV heart failure (baseline) |
| known cirrhosis |
| known HIV infection and/or AIDS |
| pregnant women |
| previously received dialysis for {my]1 mo |
| previous organ or bone marrow transplant |
| received immunosuppressive or other immunotherapy for primary renal disease or systemic vasculitis within the past 6 mo |
| previous chemotherapy or alkylating agents for systemic cancer other than non-melanoma skin cancer within 2 yr |
| previous diagnosis of multiple myeloma or renal carcinoma |
| polycystic kidney disease |
| current participation in interventional clinical trial or in a research study |
↵a Based on simplified Modification of Diet in Renal Disease (MDRD) equation.