Table 1.

Clinical studies for cinacalcet hydrochloride

StudyNo. of PatientsReduction Rate (%)Promotion of K/DOQI Treatment Goals (%)Study Design
CaPiPTH
Block et al. ( 1), 20043716.88.443.00Double-blind, placebo-controlled study
Lindberg et al. ( 2), 20052946.57.240.50Double-blind, placebo-controlled study
Moe et al. ( 3), 200566541.0Open-label study
Chertow et al. ( 6), 2006729.711.11.8047.0Open-label study
Arenas et al. ( 7), 20072813.110.470.0064.7Open-label study
Sterrett et al. ( 4), 2007996.53.647.8042.0Double-blind, placebo-controlled study
Lazar et al. ( 8), 2007358.110.129.6043.0Double-blind, placebo-controlled study
Block et al. ( 9), 200844454.0Open-label study
Fishbane et al. ( 10), 2008877.11.247.3033.0Open-label study
Messa et al. ( 11), 20083687.05.046.0059.0Open-label study
Fukagawa et al. ( 12), 2008728.110.254.3626.4Double-blind, placebo-controlled study
Shigematsu et al. ( 13), 200919952.38Open-label study
  • iPTH, intact PTH; K/DOQI, Kidney Disease Outcomes Quality Initiative.