Table 3.

Results of SNP and MCP risk haplotype analysis in carriers of the C3 R570Q mutation

SNPrs2796267rs2796268rs1962149rs859705rs7144
Nucleotide– 567 A>G- 261 A>GIVS9-78 G>AIVS12 + 638 G>Ac.2232T>C
Patient
III.7AAAAGGGGTT
III.9AAAAGGGGTT
III.10AAAAGGGGTT
IV. 12GAGAGAndTC
IV.14GAGAGAGATC
IV.16GAGAGAGATC
IV.21GAGAGAGATC
V.16aGGGGAAAACC
V.18GAGAGAGATC
  • a V0.16 is the index patient. The MCPggaac haplotype is associated with increased susceptibility for aHUS.