Table 1.

miRs with known functions in the kidneya

miRValidated TargetsExpression and Relation to Kidney DiseaseReferences
miR-15aCdc25ARat model of PKD(147)
miR-17-92 clusterPTEN and BimEnlarged kidney glomeruli, hypercellularity, mesangial expansion, proteinuria(32)
miR-30 familyCTGFHigh expression in kidney glomeruli (and loss in podocyte-specific Dicer KO)(4951,150)
miR-192ZEB1 and ZEB2Enhanced expression in diabetic mouse kidney and by TGF-β in mouse MC; enhanced expression by high glucose in human MCs(47,48,109,127,130)
miR-200 familyZEB1 and ZEB2EMT in cultured kidney and cancer cells(132138)
miR-216a, miR-217 clusterPTENEnhanced expression in diabetic mouse kidney and by TGF-β in mouse MCs(109)
miR-377PAK1 and MnSODEnhanced expression by high glucose in human MC(48)
  • a CTGF, connective tissue growth factor; EMT, epithelial to mesenchymal transition; KO, knockout; MC, mesangial cell; miR, microRNA; MnSOD, manganese superoxide dismutase; PAK1, p21-activated kinase; PKD, polycystic kidney disease; PTEN, phosphatase and tensin homolog.