Table 1.

Daptomycin (6 mg/kg) pharmacokinetic parameters after 30-min intravenous infusion when administered (1) after HD versus (2) infused during the last part of HD with LP and (3) HP dialyzers in seven patients who had ESRD and were receiving thrice-weekly HDa

ParameterStudy Arm
Control, after HD (n = 6)LP, HD (n = 7)HP, HD (n = 7)
Cmax (μg/ml)
    mean ± SD61.1 ± 7.651.4 ± 8.939.7 ± 7.6b,c
    F (%)87.7 ± 18.467.3 ± 18.6
Calculated AUC (0 to 45 h; μg* h per ml)
    mean ± SD1076.4 ± 87.7876.3 ± 86.4b711.5 ± 125.9b,c
    F (%)80.6 ± 8.064.6 ± 12.8
Half-life (h)
    mean ± SD45.5 ± 22.829.0 ± 7.834.1 ± 14.8
    range27.5 to 90.414.8 to 39.613.9 to 59.8
Tmax (h)0.50.50.5
Calculated serum concentration at 45 h (μg/ml)15.27 ± 2.6010.15 ± 3.30b9.64 ± 3.80b
  • a AUC, area under the curve; Cmax, maximum serum concentrations; F, relative bioavailability; HD, hemodialysis; HP, high-permeability; LP, low-permeability; Tmax, time to maximum serum concentration.

  • b P < 0.05 versus control.

  • c P < 0.05 versus LP.