Table 5.

Published data regarding intracyst antibiotic diffusion in patients with ADPKD

ReferenceNo. of PatientsCyst LocationAntibioticIntracystic Antibiotic Diffusion
Telenti et al. (7)3LiverCiprofloxacinGood
Concentration ratio cyst/serum 2.3 to 4.4
1ChloramphenicolGood
Concentration ratio cyst/serum 1.1
Bennett et al. (17)10KidneyAmoxicillinPoor on day 1/good on day 6
AminosidePoor
ClindamycinGood
MetronidazoleGood
BactrimGood
VancomycinGood
Elzinga et al. (18)7KidneyCiprofloxacin (oral)Good
Concentration ratio cyst/serum 2.5
Hiyama et al. (12)1KidneyAmpicillinPoor
Concentration ratio cyst/serum <0.4
LevofloxacinGood
Concentration ratio cyst/serum 0.96
Elzinga et al. (19)8KidneyTrimethoprimGood
Concentration ratio cyst/serum >8
SulfamethoxazolePoor
Concentration ratio cyst/serum 0.1 to 0.7
Schwab et al. (20)1KidneyTrimethoprimGood
Concentration ratio cyst/serum 1.6 to 23.0
SulfamethoxazolePoor
Concentration ratio cyst/serum 0.07 to 0.70
Schwab et al. (21)1KidneyClindamycinGood
Concentration ratio cyst/serum 2.4 to 8.7
GentamycinPoor
Concentration ratio cyst/serum 0.18 to 0.34