Table 5.

OR of the factors that predict the degree of Hb variability (as defined by the highest quartile of residual SD) compared with those that are associated with Hb variabilitya

VariableFactors that Predict Hb VariabilityFactors that Are Associated with Hb Variability
OR (95% CI)POR (95% CI)P
Age (per 10 yr)0.90 (0.85 to 0.96)<0.0010.89 (0.83 to 0.95)<0.001
Epoetins2.53 (2.00 to 3.19)<0.0012.59 (1.98 to 3.38)<0.001
Darbepoetin4.12 (3.32 to 5.12)<0.0013.24 (2.53 to 4.15)<0.001
Months on ESA (per 3 mo)0.95 (0.91 to 0.99)0.0350.94 (0.86 to 0.99)0.015
Baseline GFR (per 5 ml/min)Not in model0.94 (0.89 to 0.99)0.011
Variability in GFR (ml/min)1.03 (1.001 to 1.06)0.0411.19 (1.14 to 1.25)<0.001
Albumin (g/L)0.96 (0.94 to 0.97)<0.0010.95 (0.93 to 0.98)<0.001
White cell count (×109/L)1.020 (0.998 to 1.040)0.0831.07 (1.04 to 1.11)<0.001
Transferrin saturation (%)Not in model3.45 (1.31 to 9.12)0.013
  • a The values of factors 6 mo before the 6-mo baseline period were used in the model that examined the prediction of Hb variability; the values of factors during the 6-mo baseline period were used in the model that examined the association with Hb variability. OR, odds ratio.