Table 1.

Baseline demographic, clinical, laboratory, and densitometric variables according to tertiles of CACS of 137 MHD patients with CACS >0a

VariableCACSP Trend
First Tertile(1 to 131; n = 45)Second Tertile (132 to 1045; n = 45)Third Tertile (≥1046; n = 47)
Demographic
    age (yr)46±1460±1060±11<0.001
    women (%)4924380.3
    black race (%)5140470.7
    Hispanic ethnicity (%)3640260.3
    diabetes (%)366481<0.001
Nutritional measures
    total proteins71.6±35.168.4±23.465.2±28.30.3
    total calories1767.0±745.01670.0±540.01639.0±681.00.4
    BMI (kg/m2)26.5±8.525.8±4.427.7±5.20.4
    triceps skinfold (mm)17.3±10.115.1±9.016.9±9.20.8
    biceps skinfold (mm)10.7±8.58.8±6.110.0±5.80.7
    NIR-measured body fat (%)25.2±12.925.0±8.328.1±9.70.18
Hemodialysis treatment measures
    dialysis vintage <6 mo (%)71250.6
    dialysis vintage (mo)38.0±35.337.8±29.751.6±35.30.01
    dialysis dosage (Kt/V single pool)1.68±0.221.71±0.301.72±0.280.4
    nPNA or nPCR (g/kg per d)1.06±0.191.06±0.241.12±0.270.23
    systolic BP (mmHg)146±28156±23157±260.06
    diastolic BP (mmHg)79±1778±1577±160.5
Biochemical measurements (mean ± SD)
    serum albumin (g/dl)4.03±0.283.96±0.283.98±0.280.4
    transthyretin (prealbumin; mg/dl)31.9±9.728.7±8.530.1±8.30.4
    triglycerides (mg/dl)138±68144±100164±1650.3
    TC (mg/dl)156±43151±37145±430.22
    LDL (mg/dl)92±3783±2579±310.06
    HDL (mg/dl)37±939±1434±160.3
    creatinine (mg/dl)11.4±3.310.2±2.910.5±2.90.2
    ferritin (ng/ml)568±406625±475744±4060.05
    iron saturation ratio (%)36.1±11.035.8±12.134.1±10.00.4
    calcium (mg/dl)9.8±0.79.4±0.69.8±0.50.6
    phosphorus (mg/dl)5.7±1.25.6±1.35.5±1.20.5
    calcium × phosphorus (mg2/dl2)55.7±12.552.7±11.553.2±11.50.3
    intact PTH (pg/ml)349±377256±188242±1690.053
    AlkPhos (IU/L)104±51120±59126±560.08
    AlkPhos ≥120 IU/L (%)2333450.03
    serum AST (U/L)17.9±11.220.3±18.518.4±7.70.9
    bicarbonate (mg/dl)22.3±2.822.4±3.022.6±3.10.6
    total homocysteine (μmol/L)26.0±8.326.0±9.827.5±8.30.4
    CRP (mg/l)5.5±6.54.7±4.84.5±4.40.9
    IL-6 (pg/ml)22.4±95.57.9±5.411.0±8.40.04
    TNF-α (pg/ml)6.2±9.95.8±5.86.4±5.70.4
    blood hemoglobin (g/dl)12.2±0.712.5±0.712.1±0.70.3
    WBC (×1000 cell/μl)6.6±2.17.0±1.66.8±1.50.6
    lymphocyte (% of total WBC)28.3±8.423.5±6.122.5±7.8<0.001
Medications
    erythropoietin dosage (1000 U/wk)11.4±7.010.0±11.213.6±1.10.3
    paricalcitol dosage (mg/mo)69±8341±2549±530.17
  • a Data are means ± SD or percentages. P values for dialysis dosage (vintage), ferritin, CRP, IL-6, and TNF-α are based on the logarithmic values of these measures. AlkPhos, alkaline phosphatase; AST, aspartate aminotransferase; BMI, body mass index; CACS, coronary artery calcification score; CRP, C-reactive protein; Kt/V, dialysis dosage; MHD, maintenance hemodialysis; NIR, near-infrared; nPCR, normalized protein catabolic rate; PTH, parathyroid hormone; TC, total cholesterol; WBC, white blood cell.