Table 5.

Areas under the curve (AUCs) for normalized urinary biomarkers at various time pointsa

Time after CPB
Pre-OPImmediately After3 h18 h24 h
AKI (n = 36)
    KIM-10.61 (0.51 to 0.72)0.68 (0.58 to 0.78)0.65 (0.54 to 0.75)0.60 (0.49 to 0.71)0.59 (0.47 to 0.70)
    NAG0.56 (0.46 to 0.67)0.61 (0.50 to 0.71)0.63 (0.51 to 0.73)0.64 (0.52 to 0.74)0.56 (0.44 to 0.67)
    NGAL0.55 (0.45 to 0.66)0.59 (0.48 to 0.69)0.65 (0.54 to 0.76)0.70 (0.59 to 0.80)0.59 (0.47 to 0.70)
    Combined0.63 (0.52 to 0.73)0.75 (0.65 to 0.84)b0.78 (0.68 to 0.87)c0.70 (0.58 to 0.79)0.68 (0.56 to 0.78)
    Delta Scr (%)0.67 (0.56 to 0.77)0.83 (0.74 to 0.90)
Early AKI (n = 16)
    KIM-10.72 (0.60 to 0.82)0.79 (0.67 to 0.88)d0.73 (0.60 to 0.83)0.69 (0.56 to 0.80)0.71 (0.57 to 0.83)
    NAG0.58 (0.45 to 0.69)0.60 (0.47 to 0.71)0.59 (0.46 to 0.71)0.65 (0.52 to 0.77)0.54 (0.40 to 0.68)
    NGAL0.55 (0.42 to 0.67)0.51 (0.38 to 0.63)0.58 (0.45 to 0.70)0.68 (0.56 to 0.79)0.64 (0.50 to 0.77)
    Combined0.75 (0.63 to 0.85)0.80 (0.69 to 0.89)b0.84 (0.72 to 0.92)e0.83 (0.72 to 0.92)c0.78 (0.65 to 0.88)f
    Delta Scr (%)0.72 (0.60 to 0.82)1.00 (0.95 to 1.00)
Late AKI (n = 20)
    KIM-10.54 (0.42 to 0.65)0.61 (0.49 to 0.72)0.60 (0.47 to 0.71)0.54 (0.41 to 0.66)0.54 (0.40 to 0.67)
    NAG0.55 (0.43 to 0.67)0.62 (0.51 to 0.74)0.65 (0.52 to 0.76)0.62 (0.50 to 0.74)0.54 (0.41 to 0.67)
    NGAL0.56 (0.44 to 0.67)0.66 (0.54 to 0.76)0.71 (0.59 to 0.82)0.72 (0.60 to 0.82)0.62 (0.48 to 0.74)
    Combined0.54 (0.42 to 0.66)0.72 (0.60 to 0.82)0.74 (0.62 to 0.84)0.59 (0.46 to 0.71)0.65 (0.52 to 0.77)
    Delta Scr (%)0.64 (0.52 to 0.75)0.70 (0.58 to 0.80)
  • a Values are AUC (95% confidence interval for AUC).

  • b P < 0.05 versus NGAL, NAG.

  • c P < 0.05 versus KIM-1, NAG.

  • d P < 0.05 versus NGAL.

  • e P < 0.05 versus KIM-1, NAG, NGAL.

  • f P < 0.05 versus NAG.