Areas under the curve (AUCs) for normalized urinary biomarkers at various time pointsa
| Time after CPB | |||||
|---|---|---|---|---|---|
| Pre-OP | Immediately After | 3 h | 18 h | 24 h | |
| AKI (n = 36) | |||||
| KIM-1 | 0.61 (0.51 to 0.72) | 0.68 (0.58 to 0.78) | 0.65 (0.54 to 0.75) | 0.60 (0.49 to 0.71) | 0.59 (0.47 to 0.70) |
| NAG | 0.56 (0.46 to 0.67) | 0.61 (0.50 to 0.71) | 0.63 (0.51 to 0.73) | 0.64 (0.52 to 0.74) | 0.56 (0.44 to 0.67) |
| NGAL | 0.55 (0.45 to 0.66) | 0.59 (0.48 to 0.69) | 0.65 (0.54 to 0.76) | 0.70 (0.59 to 0.80) | 0.59 (0.47 to 0.70) |
| Combined | 0.63 (0.52 to 0.73) | 0.75 (0.65 to 0.84)b | 0.78 (0.68 to 0.87)c | 0.70 (0.58 to 0.79) | 0.68 (0.56 to 0.78) |
| Delta Scr (%) | 0.67 (0.56 to 0.77) | 0.83 (0.74 to 0.90) | |||
| Early AKI (n = 16) | |||||
| KIM-1 | 0.72 (0.60 to 0.82) | 0.79 (0.67 to 0.88)d | 0.73 (0.60 to 0.83) | 0.69 (0.56 to 0.80) | 0.71 (0.57 to 0.83) |
| NAG | 0.58 (0.45 to 0.69) | 0.60 (0.47 to 0.71) | 0.59 (0.46 to 0.71) | 0.65 (0.52 to 0.77) | 0.54 (0.40 to 0.68) |
| NGAL | 0.55 (0.42 to 0.67) | 0.51 (0.38 to 0.63) | 0.58 (0.45 to 0.70) | 0.68 (0.56 to 0.79) | 0.64 (0.50 to 0.77) |
| Combined | 0.75 (0.63 to 0.85) | 0.80 (0.69 to 0.89)b | 0.84 (0.72 to 0.92)e | 0.83 (0.72 to 0.92)c | 0.78 (0.65 to 0.88)f |
| Delta Scr (%) | 0.72 (0.60 to 0.82) | 1.00 (0.95 to 1.00) | |||
| Late AKI (n = 20) | |||||
| KIM-1 | 0.54 (0.42 to 0.65) | 0.61 (0.49 to 0.72) | 0.60 (0.47 to 0.71) | 0.54 (0.41 to 0.66) | 0.54 (0.40 to 0.67) |
| NAG | 0.55 (0.43 to 0.67) | 0.62 (0.51 to 0.74) | 0.65 (0.52 to 0.76) | 0.62 (0.50 to 0.74) | 0.54 (0.41 to 0.67) |
| NGAL | 0.56 (0.44 to 0.67) | 0.66 (0.54 to 0.76) | 0.71 (0.59 to 0.82) | 0.72 (0.60 to 0.82) | 0.62 (0.48 to 0.74) |
| Combined | 0.54 (0.42 to 0.66) | 0.72 (0.60 to 0.82) | 0.74 (0.62 to 0.84) | 0.59 (0.46 to 0.71) | 0.65 (0.52 to 0.77) |
| Delta Scr (%) | 0.64 (0.52 to 0.75) | 0.70 (0.58 to 0.80) | |||