Table 4.

Comparison of various normalized urinary marker levels in patients with AKI and non-AKIa

Pre-OPImmediately Post-OP3 h Post-OP18 h Post-OP24 h Post-OP
Normalized KIM-1 (ng/mg Ucr)b
    AKI1.1 (0.7 to 1.4) (n = 36)1.4 (0.1 to 2.4)c (n = 35)0.7 (0.0 to 2.1)d (n = 28)2.6 (1.2 to 4.0) (n = 34)2.1 (1.4 to 3.9) (n = 34)
    early AKI1.3 (0.8 to 1.7)d (n = 16)2.5 (0.2 to 4.5)cf (n = 15)1.5 (0.0 to 3.6)d (n = 12)4.3 (1.1 to 8.2)d (n = 15)4.2 (1.5 to 10.2)de (n = 15)
    late AKI0.8 (0.5 to 1.4) (n = 20)0.5 (0.0 to 2.0) (n = 20)0.4 (0.0 to 1.5) (n = 16)2.5 (1.1 to 3.3) (n = 19)1.6 (1.1 to 2.2) (n = 19)
    non-AKI0.8 (0.6 to 1.0) (n = 54)0.0 (0.0 to 0.6) (n = 54)0.0 (0.0 to 0.3) (n = 51)1.7 (1.3 to 2.7) (n = 48)1.7 (1.0 to 2.7) (n = 42)
Normalized NAG (U/gram Ucr)
    AKI4.7 (2.7 to 9.6) (n = 36)47.9 (28.5 to 93.9) (n = 35)19.8 (6.1 to 27.9) (n = 28)6.4 (5.3 to 9.2)d (n = 34)7.6 (4.4 to 13.9) (n = 34)
    early AKI7.6 (1.0 to 16.3) (n = 16)37.8 (18.0 to 132.3) (n = 15)20.9 (3.7 to 43.6) (n = 12)7.7 (5.1 to 12.5) (n = 15)7.3 (3.6 to 22.5) (n = 15)
    late AKI4.3 (2.4 to 9.6) (n = 20)51.9 (26.2 to 168.8) (n = 20)17.7 (5.3 to 97.8) (n = 16)5.6 (5.2 to 10.7) (n = 19)8.0 (3.5 to 13.9) (n = 19)
    non-AKI4.2 (2.1 to 5.6) (n = 54)24.9 (14.5 to 55.6) (n = 54)9.2 (5.5 to 16.5) (n = 51)4.0 (3.2 to 7.2) (n = 48)7.5 (4.7 to 10.2) (n = 42)
Normalized NGAL (ng/mg Ucr)
    AKI6.1 (2.8 to 12.0) (n = 36)4579.0 (1544.8 to 8074.2) (n = 35)2071.4 (455.4 to 6211.0)d (n = 28)71.2 (31.7 to 255.6)c (n = 34)69.6 (9.9 to 323.1) (n = 34)
    early AKI9.5 (1.4 to 85.1) (n = 16)2044.1 (36.0 to 7247.3) (n = 15)1153.3 (1.1 to 8000.0) (n = 12)70.8 (6.4 to 1418.2)d (n = 15)73.3 (8.0 to 4752.1) (n = 13)
    late AKI5.4 (2.4 to 13.1) (n = 20)7151.1 (1704.2 to 9810.8)d (n = 20)3041.7 (324.5 to 7457.0)d (n = 16)75.6 (26.5 to 251.9)d (n = 19)70.1 (9.1 to 621.6) (n = 19)
    non-AKI3.8 (2.9 to 6.7) (n = 54)2308.5 (344.1 to 5044.8) (n = 54)130.6 (35.9 to 601.9) (n = 51)15.8 (9.0 to 22.0) (n = 48)20.9 (13.8 to 31.6) (n = 42)
Delta Scr (%)
    AKI−10.00 (−10.00 to 0.00)d (n = 34)−20.00 (10.00 to 31.45)c (n = 36)
    early AKI0.00 (−20.00 to 7.60)d (n = 14)40.00 (30.00 to 70.00)c (n = 16)
    late AKI−10.00 (−20.00 to 0.00) (n = 20)5.00 (−10.00 to 15.50)d (n = 20)
    non-AKI−20.00 (−20.00 to −10.00) (n = 54)−10.00 (−20.00 to 0.00) (n = 54)
  • a Values are medians (95% confidence interval for median).

  • b Ucr, urine creatinine concentration.

  • c P < 0.005 versus non-AKI.

  • d P < 0.05 versus non-AKI.

  • e P < 0.005 versus late AKI.

  • f P < 0.05 versus late AKI.