Table 2.

Time course of pharmacodynamic parameters on day −2 and day −1

Day −2Day −1
Median25th Percentile75th PercentilePMedian25th Percentile75th PercentileP
IMPDH_0 h14.312.017.914.112.317.4
IMPDH_1 h15.712.417.54.02.56.4
IMPDH_2 h16.013.118.25.33.88.4
IMPDH_4 h16.112.918.1n.s.8.75.413.50.0001
IL-2_0 h35.329.648.132.924.449.3
IL-2_1 h35.228.453.237.426.645.0
IL-2_2 h37.928.155.536.928.643.6
IL-2_4 h43.428.554.5n.s.39.228.448.1n.s.
TNF-alpha_0 h25.820.138.521.313.539.3
TNF-alpha_1 h29.119.134.527.819.139.6
TNF-alpha_2 h28.823.536.927.221.242.0
TNF-alpha_4 h29.723.636.2n.s.27.918.435.60.001
CD25_0 h39.831.059.033.926.349.3
CD25_1 h45.433.360.722.818.331.6
CD25_2 h40.132.760.128.219.335.8
CD25_4 h47.036.265.10.0534.624.246.60.0001
CD71_0 h26.518.733.018.714.432.5
CD71_1 h30.921.436.013.210.014.1
CD71_2 h28.320.237.614.011.319.4
CD71_4 h37.417.943.20.0519.012.628.80.0001
Proliferation_0 h12.97.618.312.37.018.4
Proliferation_1 h12.89.118.20.80.51.4
Proliferation_2 h14.69.420.41.00.53.4
Proliferation_4 h16.27.923.80.059.34.013.50.0001
  • IMPDH, inosine monophosphate dehydrognase.