Table 1.

Formula for fitted multiple logistic regression model for combining biomarkersa

For AKI (n = 36) versus all non-AKI (n = 54) combined
    pre-OP[−0.9596 + 0.01386 × NAG + 0.3102 × KIM1 + 0.0006661 × NGAL]
    immediately post-OP[−2.0269 + 0.001718 × NAG + 0.7716 × KIM1 + 0.0001331 × NGAL]
    3 h post-OP[−2.0673 + 0.01182 × NAG + 1.0965 × KIM1 + 0.00009982 × NGAL]
    18 h post OP[−1.6097 + 0.03977 × NAG + 0.2894 × KIM1 + 0.0005103 × NGAL]
    24 h post-OP[−0.5933 + 0.007838 × NAG + 0.06978 × KIM1 + 0.0008006 × NGAL]
For early AKI (n = 16) versus all non-AKI (n = 54) combined
    pre-OP[−2.0360 − 0.0005436 × NAG + 0.5281 × KIM1 + 0.0008857 × NGAL]
    immediately post-OP[−3.3182 + 0.00212 × NAG + 1.088 × KIM1 + 0.00009552 × NGAL]
    3 h post-OP[−3.4557 + 0.01294 × NAG + 1.4386 × KIM1 + 0.0001215 × NGAL]
    18 h post-OP[−3.8619 + 0.06381 × NAG + 0.5328 × KIM1 + 0.0008294 × NGAL]
    24 h post-OP[−2.2619 − 0.01722 × NAG + 0.2097 × KIM1 + 0.0007784 × NGAL]
For late AKI (n = 20) versus all non-AKI (n = 54) combined
    pre-OP[−1.3241 + 0.01832 × NAG + 0.1329 × KIM1 + 0.0003802 × NGAL]
    immediately post-OP[−2.4918 + 0.002208 × NAG + 0.6224 × KIM1 + 0.0001534 × NGAL]
    3 h post-OP[−2.4066 + 0.01427 × NAG + 0.977 × KIM1 + 0.00006504 × NGAL]
    18 h post-OP[−1.3878 + 0.03679 × NAG + 0.08044 × KIM1 + 0.00009971 × NGAL]
    24 h post-OP[−0.5948 − 0.0148 × NAG - 0.2848 × KIM1 + 0.0008516 × NGAL]
  • a AKI, acute kidney injury; OP, open-heart operation; KIM-1, kidney injury molecule-1; NAG, N-acetyl-β-D-glucosaminidase; NGAL, neutrophil gelatinase associated lipocalin.