Table 4.

Renal function as assessed by serum creatinine (SCr) and 24-h urine creatinine clearance (ClCr) over the 5-year study period in hypertensive (HBP) and normotensive (NBP) subjects with ADPKD

HBPNBP
NYear 02857
Year 52042
SCr (mg/dl)Year 00.73 (0.69–0.79)0.70 (0.67–0.74)
Year 50.98 (0.90–1.06)a0.75 (0.71–0.79)bc
ClCr (ml/min/1.73 m2)Year 0129 (121–138)135 (128–141)
Year 598 (90–106)125 (119–132)d
Δ SCr (mg/dl/yr)0.03 ± 0.010.00 ± 0.0a
Δ ClCr (ml/min/1.73 m2/yr)−6.1 ± 1.3−1.4 ± 0.9e
  • Values for serum creatinine (SCr) and creatinine clearance (ClCr) are geometric mean with 95% confidence interval. Values for ΔSCr and ΔClCr are mean ± SEM.

  • a HBP Year 0 vs. Year 5.

  • b HBP vs. NBP, P < 0.0001.

  • c NBP Year 0 vs. Year 5, P < 0.05.

  • d NBP Year 0 vs. Year 5, P < 0.02.

  • e HBP vs. NBP, P < 0.004. P < 0.0001.