Table 2.

Systolic blood pressure (SBP), SBP index, diastolic blood pressure (DBP), DBP index, renal volume by ultrasound, left ventricular mass index (LVMI) by echocardiography, and urine microalbumin (UMA) excretion over the 5-year study period in the different treatment arms

ABC
HBP50HBP90BBP + ACEIBBP-ACEISPKD + ACEISPKD-ACEI
N
    baseline141415121515
    year 51010981312
SBP (mmHg)
    baseline131 ± 4129 ± 4119 ± 3119 ± 3109 ± 2110 ± 2
    year 5125 ± 4137 ± 4a122 ± 3132 ± 3h,l117 ± 2118 ± 3
SBP index
    baseline1.02 ± 0.021.00 ± 0.020.95 ± 0.020.94 ± 0.020.86 ± 0.010.87 ± 0.01
    year 50.93 ± 0.03d1.03 ± 0.040.89 ± 0.02k0.96 ± 0.02h0.86 ± 0.010.90 ± 0.02
DBP (mmHg)
    baseline70 ± 274 ± 2b68 ± 267 ± 265 ± 263 ± 2
    year 567 ± 277 ± 2b71 ± 278 ± 2h,m68 ± 271 ± 2
DBP index
    baseline0.85 ± 0.020.86 ± 0.030.85 ± 0.020.83 ± 0.020.79 ± 0.010.77 ± 0.02
    year 50.77 ± 0.03c0.86 ± 0.040.78 ± 0.02k0.87 ± 0.02i0.74 ± 0.02o0.83 ± 0.02n,r
BP goal met based on home reports
    year 54/107/109/98/88/1312/12
Renal volume corrected for BSA (ml/1.73 m2)
    baseline255 (189–344)328 (243–443)188 (152–231)193 (153–244)184 (151–225)194 (156–240)
    year 5399 (290–550)e500 (366–682)g276 (222–342)j290 (227–372)l307 (251–376)p342 (273–428)q
Change in renal volume per year corrected for BSA (ml/1.73 m2/yr)43 ± 3044 ± 3020 ± 1121 ± 1424 ± 1928 ± 21
Percent change in renal volume per year corrected for BSA (%/1.73 m2/yr)10.5 ± 8.88.7 ± 8.96.6 ± 5.38.1 ± 6.69.4 ± 5.711.6 ± 6.2
Renal volume adjusted for sex and height (ml)
    baseline246 (174–350)315 (226–439)157 (125–196)168 (132–214)162 (133–198)177 (142–220)
    year 5417 (290–600)e516 (366–727)f231 (184–290)j263 (202–342)l260 (214–318)p311 (248–391)q
LVMI (g/m2)
    baseline76 (68–84)76 (69–84)76 (68–84)66 (59–74)61 (55–68)61 (55–68)
    year 579 (69–90)80 (71–90)77 (69–87)77 (67–88)l75 (67–83)o71 (62–80)s
UMA (mcg/day)
    baseline21 (14–32)32 (20–50)17 (9–32)26 (14–48)36 (22–60)19 (11–34)
    year 529 (18–46)40 (25–63)29 (11–35)23 (12–46)22 (14–36)p20 (11–36)
SCr (mg/dl)
    baseline0.70 (0.63–0.78)0.78 (0.71–0.85)0.77 (0.69–0.85)0.67 (0.60–0.74)0.66 (0.61–0.72)0.69 (0.63–0.76)
    year 50.98 (0.88–1.10)e1.03 (0.93–1.15)g0.73 (0.66–0.82)0.80 (0.70–0.90)l0.73 (0.67–0.80)0.68 (0.61–0.76)
ClCr (ml/min/1.73 m2)
    baseline142 (129–156)128 (117–140)122 (111–135)135 (121–150)138 (127–150)137 (125–149)
    year 5101 (90–112)e97 (88–108)g126 (113–140)114 (100–129)l127 (117–138)136 (123–151)
  • A: hypertensive ADPKD children randomized to treatment with enalapril to goal blood pressure at the 50th percentile (HBP50) versus goal blood pressure at the 90th percentile (HBP90). B: borderline hypertensive children randomized to treatment with enalapril to goal blood pressure at or below the 50th percentile (BBP + ACEI) versus no treatment (BBP-ACEI): C: severe ADPKD children randomized to treatment with enalapril (SPKD + ACEI) versus no treatment (SPKD-ACEI). Values for renal volume (ml), LVMI, and UMA are geometric mean with 95% confidence interval adjusted for height and sex. Values for renal volume (ml/1.73 m2) and change in renal volume over time (ml/1.73 m2/yr) represent renal volume corrected for body surface area and are not adjusted for height or sex.

    P values:

  • a HBP50 vs. HBP90, P < 0.05.

  • b HBP50 vs. HBP90, P < 0.01.

  • c HBP50 year 5 vs. baseline, P < 0.05.

  • d HBP50 year 5 vs. baseline, P < 0.01.

  • e HBP50 year 5 vs. baseline, P < 0.0001.

  • f HBP90 year 5 vs. baseline, P < 0.05.

  • g HBP90 year 5 vs. baseline, P < 0.0001.

  • h BBP + ACEI vs. BBP-ACEI, P < 0.05.

  • i BBP + ACEI vs. BBP-ACEI, P < 0.01.

  • j BBP + ACEI year 5 vs. baseline, P < 0.05.

  • k BBP + ACEI, year 5 vs. baseline, P < 0.01.

  • l BBP-ACEI year 5 vs. baseline, P < 0.05.

  • m BBP-ACEI year 5 vs. baseline, P < 0.01.

  • n SPKD + ACEI vs. SPKD-ACEI, P < 0.01.

  • o SPKD + ACEI year 5 vs. baseline, P < 0.01.

  • p SPKD + ACEI, year 5 vs. baseline, P < 0.0001.

  • q SPKD-ACEI, year 5 vs. baseline, P < 0.05.

  • r SPKD-ACEI, year 5 vs. baseline, P < 0.01.

  • s SPKD-ACEI, year 5 vs. baseline, P < 0.05.