Table 1.

Baseline characteristics of hypertensive (HBP), borderline hypertensive (BBP), and severe ADPKD (SPKD) subjects

ParameterHBPBBPSPKDp-value for ANOVA
N282730
Male/female17/1115/1213/17NS
Age (years)14 ± 112 ± 112 ± 1NS
Height (cm)160 ± 4151 ± 5151 ± 5NS
SBP (mmHg)130 ± 3119 ± 2109 ± 2<0.0001
DBP (mmHg)72 ± 268 ± 164 ± 1<0.0002
SBP index1.01 ± 0.020.95 ± 0.010.87 ± 0.01<0.0001
DBP index0.86 ± 0.020.84 ± 0.010.78 ± 0.01<0.0004
Serum creatinine (mg/dl)0.74 (0.68–0.81)0.69 (0.62–0.77)0.66 (0.57–0.70)NS
24-h urine creatinine clearance (ml/min/1.73 m2)130 (120–141)127 (117–138)135 (127–145)NS
Total renal volume corrected for BSA (ml/1.73m2)289 (247–339)190 (162–223)188 (162–220)<0.0002
Total renal volume (ml)238 (206–275)163 (141–188)156 (136–180)<0.0001
LVMI (g/m2)75 (70–80)71 (66–76)61 (57–66)<0.0004
UMA (mcg/day)23 (16–33)22 (14–35)31 (19–51)NS
  • Values for total renal volume corrected by body surface area are geometric mean (95% confidence interval). All others are height- and sex-adjusted mean ± SEM or geometric mean (95% confidence interval). ADPKD, autosomal dominant polycystic kidney disease; SBP, systolic blood pressure. DBP, diastolic blood pressure. US, ultrasound. BSA, body surface area. LVMI, left ventricular mass index. UMA, urine microalbumin excretion. NS, not significant.

    SBP: HBP vs. BBP, P < 0.002; HBP vs. SPKD, P < 0.0001; BBP vs. SPKD, P < 0.0001

    DBP: HBP vs. BBP, pNS; HBP vs. SPKD, P < 0.0003; BBP vs. SPKD, P < 0.05

    SBP index: HBP vs. BBP, P < 0.003; HBP vs. SPKD, P < 0.0001; BBP vs. SPKD, P < 0.0001

    DBP index: HBP vs. BBP, pNS; HBP vs. SPKD, P = 0.0005; BBP vs. SPKD, P < 0.007

    Renal volume corrected for BSA (ml/1.73 m2): HBP vs. BBP, P = 0.0012; HBP vs. SPKD, P = 0.0007; BBP vs. SPKD, pNS

    Renal volume adjusted for sex and height: HBP vs. BBP, P < 0.002; HBP vs. SPKD, P = 0.0002; BBP vs. SPKD, pNS

    LVMI: HBP vs. BBP, pNS; HBP vs. SPKD, P = 0.0005; BBP vs. SPKD, P < 0.02