Table 2.

Effect of target hemoglobin on quality of life scores

Baseline ValuesChange from Baseline in High Target (vs. Change from Baseline in Low Target) WeekP1
Target Hemoglobin g/dl
10.5 - 11.513.5 - 14.524364860728496
Burden of kidney disease47.144.82.41.03.72.24.9*1.62.10.34
(2.0)(2.0)(2.0)(2.0)(2.0)(2.1)(2.2)(2.2)(2.2)
Quality of social interaction66.662.80.62.90.91.40.81.91.10.76
(2.2)(2.3)(1.7)(1.7)(1.7)(1.8)(1.8)(1.9)(1.9)
Cognitive function69.963.32.93.8*2.24.7**2.52.44.3*0.20
(2.3)(2.4)(1.7)(1.7)(1.7)(1.8)(2.5)(1.9)(1.9)
Symptoms/problems80.380.00.5-0.50.1-0.3-0.11.30.20.91
(1.0)(1.1)(1.2)(1.3)(1.3)(1.3)(1.30)(1.4)(1.4)
Effects of kidney disease64.665.2-0.21.2-0.7-0.11.71.10.50.77
(1.5)(1.5)(1.5)(1.5)(1.6)(1.6)(1.6)(1.7)(1.7)
Sexual function69.362.32.64.55.64.46.5*3.15.60.54
(2.6)(2.7)(2.9)(3.0)(3.0)(3.1)(3.2)(3.3)(3.3)
Sleep67.964.7-0.51.0-1.0-0.9-0.3-1.7-2.00.72
(1.4)(1.4)(1.7)(1.7)(1.7)(1.8)(1.8)(1.9)(1.8)
Social support75.274.00.61.12.30.40.21.7-1.60.92
(1.7)(1.8)(2.7)(2.7)(2.7)(2.8)(2.9)(2.9)(2.9)
Work status40.334.41.4-0.64.24.01.61.05.20.39
(3.0)(3.1)(2.9)(3.0)(3.0)(3.1)(3.2)(3.2)(3.2)
Dialysis staff82.679.73.0-0.30.42.91.42.71.10.49
    encouragement(1.5)(1.5)(2.0)(2.0)(2.0)(2.1)(2.1)(2.2)(2.2)
Patient satisfaction rating75.977.3-0.8-0.20.4-2.60.50.1-1.20.76
(1.5)(1.6)(1.9)(1.9)(2.0)(2.0)(2.1)(2.1)(2.1)
Overall health rating62.062.00.31.51.70.12.51.60.50.76
(1.4)(1.5)(1.9)(1.9)(1.9)(2.0)(2.0)(2.1)(2.1)
Physical functioning67.162.53.14.6*3.54.04.4*5.1*2.40.32
(1.8)(1.9)(2.0)(2.0)(2.0)(2.1)(2.1)(2.2)(2.2)
Role limitations -physical48.447.73.61.23.75.85.69.7*-1.30.33
(3.1)(3.2)(4.4)(4.4)(4.4)(4.5)(4.7)(4.8)(4.8)
Pain72.070.7-2.51.4-0.9-2.23.50.6-0.70.34
(2.0)(2.0)(2.6)(2.6)(2.7)(2.7)(2.8)(2.9)(2.9)
General health49.448.61.31.63.21.24.0*1.20.60.35
(1.6)(1.6)(1.7)(1.7)(1.7)(1.8)(1.8)(1.9)(1.9)
Emotional well-being74.067.81.72.23.9*2.14.5*2.70.70.21
(1.4)(1.6)(1.8)(1.8)(1.8)(1.8)(1.9)(1.9)(1.9)
Role limitations -emotional68.469.1-3.8-2.1-1.70.40.61.3-0.80.95
(3.0)(3.0)(4.4)(4.4)(4.4)(4.5)(4.7)(4.8)(4.8)
Social function74.571.42.01.23.15.8*4.81.11.30.25
(1.7)(1.9)(2.4)(2.5)(2.5)(2.5)(2.6)(2.7)(2.7)
Energy/fatigue57.953.96.2**5.7**3.8*5.4**7.9***5.4*3.20.0066
(1.5)(1.7)(1.9)(1.9)(1.9)(2.0)(2.1)(2.1)(2.1)
  • Repeated measures analysis of variance with mixed modeling was used to estimate changes in quality of life over time. Positive values represent improvements in quality of life. Parameter estimates are presented with standard errors in parentheses.

  • * P < 0.05,

  • ** P < 0.01,

  • *** P < 0.001,

  • P < 0.0001 for the effect of target hemoglobin at week 24, 36, 48, 72, or 96.