Table 2.

Comparison of laboratory data from the 12 mo before conversion to INHD with the intervals up to 12 mo after conversion to INHDa

Parameter12 Mo before INHDBaseline at Conversion3 Mo after INHD6 Mo after INHD9 Mo after INHD12 Mo after INHDPa
N393933282625
PRU (%)b0.74 (0.69 to 0.78)0.76 (0.71 to 0.82)0.88 (0.71 to 0.91)0.89 (0.87 to 0.90)0.90 (0.85 to 0.93)0.89 (0.79 to 0.93)<0.01
Corrected calcium (mg/dl)9.6 (9.1 to 10.0)9.5 (9.1 to 10.2)9.4 (9.2 to 9.7)9.6 (8.9 to 9.8)9.2 (9.0 to 9.6)9.3 (9.2 to 9.8)NS
Phosphorus (mg/dl)5.9 (4.3 to 7.5)5.4 (3.6 to 6.9)5.0 (4.4 to 6.3)4.7 (4.2 to 5.9)4.4 (3.8 to 6.7)3.7 (3.3 to 5.0)<0.01
C × P (mg2/dl2)56.6 (39.1 to 75.0)51.3 (32.8 to 70.4)47 (40.5 to 61.1)45.1 (37.4 to 57.8)40.5 (34.2 to 64.3)34.4 (30.4 to 49.0)<0.01
PTH (pg/ml)220.9 (75.5 to 391.8)234.5 (93.6 to 525.5)340 (197.3 to 357.3)302.7 (102.7 to 547.3)311.8 (241.8 to 697.3)326.4 (117.3 to 643.6)NS
AP (U/L)84 (63 to 129)102 (74 to 168)122 (74 to 158)142 (105 to 245)134 (107 to 201)161 (105 to 234)<0.01
Hemoglobin (g/dl)11.5 (10.6 to 12.2)11.5 (10.2 to 12.7)11.7 (10.7 to 12.4)11.7 (10.5 to 12.9)11.9 (11.2 to 13.0)12.6 (11.4 to 12.8)NS
Iron saturation (%)0.22 (0.17 to 0.29)0.24 (0.16 to 0.34)0.22 (0.18 to 0.34)0.29 (0.19 to 0.36)0.29 (0.18 to 0.30)0.27 (0.19 to 0.30)NS
  • a Statistical analysis, by repeated measures, included all of the data to study end. To convert phosphorus in mg/dl to mmol/L, multiply by 0.323; calcium in mg/dl to mmol/L, multiply by 0.25; parathyroid hormone in pg/ml to pmol/L, multiply by 0.11; ferritin in ng/ml to pmol/L, multiply by 2.247; hemoglobin in g/dl to g/L, multiply by 10; albumin in g/dl to g/L, multiply by 10. AP, alkaline phosphatase; C × P, calcium-phosphorus product; PTH, parathyroid hormone.

  • b PRU, percent reduction of urea.