Table 4.

Factors associated with B cell depletion 1 mo after rituximab initiation

FactorB cell depletion at M1P
+-
(n = 12)(n = 5)
Median age, years (range)23 (18 to 35)24 (17 to 37)NS
Black ethnicity, n (%)2 (17%)4 (80%)0.027
Median Pu, g/j (range)5.7 (0.2 to 25)8 (2.7 to 9.5)NS
Median serum Alb, g/L (range)24.5 (20 to 40)18 (11 to 27)0.03
Median eGFR, ml/min/1.73 m2 (range)70 (9 to 150)102 (16 to 133)NS
Median C3, % normal (range)44 (15 to 96)39 (30 to 130)NS
Median C4, % normal (range)34 (17 to 78)26 (21 to 101)NS
  • B cell depletion is defined as CD19 + cells ≤5/mm3 and ≤1%. P values are by Fisher's exact test for categorical data and by Wilcoxon rank sum test with continuity correction for continuous data. NS, not significant; Pu, baseline proteinuria; Serum Alb, baseline albuminemia; eGFR, baseline estimated glomerular filtration rate; C3: baseline C3 complement; C4: baseline C4 complement.