Table 1.

Characteristics of the study population overall and according to the mean monthly percentage change in Epoetin alfa (EPO) dose over the sub-11 perioda

VariableOverall (n = 6133; mean %)Mean Monthly Change in EPO Dose (%)b
< 0 (n = 746)0 to 12.5 (n = 1432)>12.5 to 25 (n = 1491)>25 to 37.5 (n = 981)>37.5 (n = 1483)
Age (yr)59.3 (15)56.2 (15.0)58.8 (15.0)59.8 (14.7)60.1 (14.8)60.5 (14.7)
Female gender52.051.153.851.851.551.1
Race
    black47.748.848.748.746.945.7
    white43.641.742.344.046.444.5
    other8.79.510.1%7.36.79.8
Body mass index (kg/m2)27.5 (8.5)28.3 (9.9)27.9 (8.5)27.7 (8.7)27.4 (7.9)26.7 (7.8)
Diabetes as primary cause of ESRD35.233.835.135.436.332.2
Initiated dialysis within 1 yr of entry period16.216.916.817.817.513.0
Months on dialysis45.1 (42.6)45.5 (43.1)44.1 (39.8)45.9 (45.6)43.4 (41.9)46.2 (42.4)
Vascular access type at end of month 6
    catheter28.930.428.728.930.927.2
    fistula24.222.022.025.125.225.8
    graft46.947.649.346.043.947.0
Mean albumin (g/dl)
    months 1 to 33.8 (0.4)3.7 (0.4)3.7 (0.4)3.8 (0.4)3.8 (0.3)3.9 (0.3)
    months 4 to 63.7 (0.4)3.7 (0.4)3.7 (0.4)3.7 (0.4)3.8 (0.4)3.8 (0.4)
Mean ferritin (ng/ml)
    months 1 to 3585 (469)587 (680)544 (423)573 (438)582 (433)638 (427)
    months 4 to 6663 (516)628 (625)617 (547)643 (468)657 (464)749 (494)
Mean TSAT (%)
    months 1 to 328.2 (11.8)26.5 (13.3)26.2 (11.1)28.4 (11.8)28.5 (11.3)30.4 (11.5)
    months 4 to 625.8 (11.5)25.0 (12.6)24.3 (11.3)25.8 (11.4)26.0 (11.2)27.5 (11.2)
Mean iron dose (mg)
    months 1 to 397.9 (53.2)102 (61.8)98.1 (53.2)96.1 (48.6)96.0 (50.7)99.2 (54.9)
    months 4 to 699.1 (53.2)106 (73.7)99.1 (42.7)97.0 (42.1)97.2 (39.2)99.3 (67.1)
Mean hemoglobin (g/dl)
    months 1 to 311.4 (1.2)10.4 (1.4)11.1 (1.2)11.4 (1.0)11.6 (1.0)12.0 (0.8)
    months 4 to 610.0 (0.6)9.7 (0.8)10.0 (0.7)10.0 (0.6)10.0 (0.6)10.0 (0.5)
Month-3 mean EPO dose (units)6996 (6102)13,503 (8405)8928 (6187)6586 (4576)5545 (4164)3230 (2892)
Any hospitalization
    months 1 to 332.145.234.929.915.226.1
    months 4 to 645.851.647.644.245.043.2
  • a Values in parentheses indicate SD.

  • b Geometric mean.

    TSAT, transferrin saturation; URR, urea reduction ratio.