Table 2.

Baseline patients’ characteristics

CharacteristicOverall (N = 1253)With Sinus Rhythm (n = 1112)Without Sinus Rhythm (n = 141)PWithout LVH (n = 1098)With LVH (n = 155)P
Age, mean yr (SD)65.7 (8.3)65.3 (8.3)69.0 (6.8)<0.00165.6 (8.4)66.5 (7.4)0.179
Female, no. (%)577 (46)510 (45.9)67 (47.5)0.723522 (47.5)55 (35.5)0.006
Duration of diabetes, mean yr (SD)18.1 (8.8)18.2 (8.9)17.7 (8.4)0.58517.9 (8.9)19.9 (8.3)0.007
Time on dialysis, mean mo (SD)8.3 (6.9)8.2 (6.9)9.1 (6.6)0.1288.4 (7.0)7.7 (6.4)0.273
Blood pressure, mean (SD), mmHg
    systolic146 (22)146 (22)140 (20)<0.001145 (22)152 (23)<0.001
    diastolic76 (11)76 (11)75 (11)0.19676 (11)77 (12)0.122
Smoker (current/former), no. (%)506 (40.4)449 (40.4)57 (40.4)0.360430 (39.2)76 (49.0)0.059
Body mass index, mean kg/m2 (SD)27.6 (4.8)27.6 (4.8)27.6 (4.7)0.90928.0 (4.8)24.4 (3.4)<0.001
MI, CABG/ PCI, CHD, no.(%)369 (29.4)318 (28.6)51 (36.2)0.077313 (28.5)56 (36.1)0.060
Congestive heart failure, no. (%)444 (35.4)372 (33.5)72 (51.1)<0.001380 (34.6)64 (41.3)0.107
History of cardiac valve disorder, no. (%)94 (7.5)73 (6.6)21 (14.9)0.00178 (7.1)16 (10.3)0.190
Peripheral vascular disease, no. (%)560 (44.7)494 (44.4)66 (46.8)0.591486 (44.3)74 (47.7)0.438
Stroke/transitory ischemic attack, no. (%)224 (17.9)202 (18.2)22 (15.6)0.559201 (18.3)23 (14.8)0.316
Hemoglobin, mean g/dl (SD)10.9 (1.3)10.9 (1.3)11.0 (1.4)0.24010.9 (1.3)10.7 (1.4)0.023
Gycated hemoglobin, mean % (SD)6.7 (1.3)6.7 (1.3)6.9 (1.2)0.0546.7 (1.3)6.8 (1.3)0.396
Albumin, mean g/L (SD)3.8 (0.3)3.8 (0.3)3.9 (0.3)0.0203.8 (0.3)3.8 (0.3)0.507
Phosphate, mean mg/dl (SD)6.0 (1.6)6.0 (1.6)5.9 (1.8)0.4026.0 (1.6)6.0 (1.6)0.612
LDL cholesterol, mean mg/dl (SD)126 (30)126 (30)122 (30)0.108126 (30)125 (30)0.872
Dose of erythropoietin, IU/wk (SD)6,030 (3,883)5,975 (3,810)6,489 (4,433)0.2145975 (3878)6404 (3904)0.210
Arteriovenous fistula, no. (%)1168 (93.3)1041 (93.7)127 (90.1)0.1091026 (93.5)142 (91.6)0.390
Ultrafiltration volume, kg/dialysisa2.3 (1.2)2.2 (1.2)2.3 (1.3)0.5202.2 (1.2)2.3 (1.1)0.540
Duration of dialysis, hr/wk12.3 (1.9)12.3 (1.9)12.3 (2.1)0.95812.3 (1.9)12.3 (2.1)0.993
ECG signs of LVH, no. (%)-145 (13)10 (7.1)0.042---
ECG signs of MI, no. (%)176 (14.0)141 (12.7)35 (24.8)<0.001155 (14.1)21 (13.5)0.902
  • The two P values (comparing patients with sinus rhythm to those without, and patients with LVH to those without) were derived by ttest for continuous data and by the Fisher exact test or chi-square test for categorical data. Congestive heart failure is predominantly New York Heart Association II. To convert hemoglobin values to millimoles per liter, multiply by 0.62. To convert values for phosphate to millimoles per liter, multiply by 0.32. To convert values for LDL cholesterol to millimoles per liter, multiply by 0.03. Abbreviations: LVH, left ventricular hypertrophy; MI, myocardial infarction; CABG, coronary artery bypass grafting; PCI, percutaneous coronary intervention; CHD, coronary heart disease documented by coronary angiography.

  • a The ultrafiltration volume was calculated on the basis of body weight before and after dialysis at the randomization visit