Table 2.

Univariate odds ratios with 95% confidence intervals comparing each histologic type to kidneys with no evidence of thrombosis or TMA in the kidney at autopsy

FactorNegative (n = 203) N (%)Isolated renal thrombosis (n = 47)TMA (n = 64)
N (%)OR (95% CI)N (%)OR (95% CI)
Baseline characteristics
    patient/donor gender
    male/male86 (42)16 (34)1.027 (42)1.0
    male/ female44 (22)8 (17)1.0 (0.4 to 2.5)10 (16)0.7 (0.3 to 1.6)
    female/female51 (25)13 (28)1.4 (0.6 to 3.1)11 (17)0.7 (0.3 to 1.5)
    female/male22 (11)10 (21)2.4 (1.0 to 6.1)16 (25)2.3 (1.1 to 5.0)
    donor type
        related-matched63 (31)21 (45)1.022 (34)1.0
        related-mismatched26 (13)9 (19)1.0 (0.4 to 2.6)9 (14)1.0 (0.4 to 2.4)
        unrelated70 (34)14 (30)0.6 (0.3 to 1.3)31 (48)1.3 (0.7 to 2.4)
        autologous/id twin44 (22)3 (6)0.2 (0.1 to 0.7)2 (3)0.1 (0.03 to 0.6)
    TBI conditioning (cGy)
        none84 (41)16 (34)1.015 (23)1.0
        200 to 120053 (26)9 (19)0.9 (0.4 to 2.2)16 (25)1.7 (0.8 to 3.7)
        1240 to 135054 (27)13 (28)1.3 (0.6 to 2.8)27 (42)2.8 (1.4 to 5.7)
        > 135012 (6)9 (19)3.9 (1.4 to 10.9)6 (9)2.8 (0.9 to 8.6)
Median (range)Median (range)Median (range)
    agea43.1 (0.6 to 67.1)46.4 (0.9 to 67.8)1.1 (0.9 to 1.4)37.3 (1.3 to 67.1)0.8 (0.7 to 1.0)
Post-transplant features
    acute GVHD grade
        0, I48 (24)4 (9)1.06 (10)1.0
        II to IV109 (54)39 (85)4.3 (1.5 to 12.7)53 (87)3.9 (1.6 to 9.7)
        autologous/ id twin44 (22)3 (7)0.8 (0.2 to 3.9)2 (3)0.4 (0.1 to 1.9)
    ADV infection
        no174 (86)39 (83)1.049 (77)1.0
        yes29 (14)8 (17)1.2 (0.5 to 2.9)15 (23)1.8 (0.9 to 3.7)
    CMV infection
        no171 (84)34 (72)1.046 (72)1.0
        yes32 (16)13 (28)2.0 (1.0 to 4.3)18 (28)2.1 (1.1 to 4.1)
    HSV infection
        no164 (81)37 (79)1.055 (86)1.0
        yes39 (19)10 (21)1.1 (0.5 to 2.5)9 (14)0.7 (0.3 to 1.5)
    varicella virus infection
        no197 (97)46 (98)1.060 (94)1.0
        yes6 (3)1 (2)0.7 (0.1 to 6.1)4 (6)2.2 (0.6 to 8.0)
    received acyclovir
        No39 (20)10 (22)1.010 (16)1.0
        Yes159 (80)36 (78)0.9 (0.4 to 1.9)51 (84)1.3 (0.6 to 2.7)
    received amphotericin
    no72 (35)16 (34)1.017 (27)1.0
    yes131 (65)31 (66)1.1 (0.5 to 2.1)47 (73)1.5 (0.8 to 2.8)
    acute kidney injury
        no122 (60)34 (72)1.030 (47)1.0
        yes81 (40)13 (28)0.6 (0.3 to 1.2)34 (53)1.7 (1.0 to 3.0)
Two weeks before death
    Bacterial infection
        no133 (66)30 (64)1.048 (75)1.0
        yes70 (34)17 (36)1.1 (0.6 to 2.1)16 (25)0.6 (0.3 to 1.2)
    fungal infection
        no176 (87)44 (94)1.059 (92)1.0
        yes27 (13)3 (6)0.4 (0.1 to 1.5)5 (8)0.6 (0.2 to 1.5)
    incidence of dialysis
    no152 (75)34 (72)1.046 (72)1.0
    yes51 (25)13 (28)1.1 (0.6 to 2.3)18 (28)1.2 (0.6 to 2.2)
    incidence of intubation
        no122 (60)30 (64)1.043 (67)1.0
        yes81 (40)17 (36)0.9 (0.4 to 1.6)21 (33)0.7 (0.4 to 1.3)
Median (range)Median (range)Median (range)
    mean bilirubinb4.8 (0.4 to 59.6)5.4 (0.6 to 43.8)1.1 (0.8 to 1.5)5.5 (0.5 to 52.1)1.1 (0.8 to 1.4)
    mean serum creatinine1.52 (0.40 to 5.79)1.56 (0.27 to 4.57)0.9 (0.7 to 1.2)1.67 (0.55 to 4.74)1.1 (0.9 to 1.4)
  • a Estimate represents the ratio of odds for two patients, one 10 yr older than the other at transplant.

  • b Estimate represents the ratio of odds for two patients, one with mean bilirubin 10 points higher than the other.