Table 1.

Patient and transplant characteristics of the study cohort (N = 314)

FactorNumber (%)
Baseline characteristics
    age in years (median & range)42.7 (0.6 to 67.8)
    diagnosis
        hematologic malignancies160 (51%)
        myelodysplastic syndrome48 (15%)
        lymphoma43 (14%)
        multiple myeloma28 (9%)
        aplastic anemia11 (3.5%)
        other24 (7.5%)
    patient/donor gender
        male/male129 (41)
        male/female62 (20)
        female/female75 (24)
        female/male48 (15)
    Donor type
        related-matched106 (34)
        related-mismatched44 (14)
        unrelated115 (37)
        autologous/id twin49 (15)
    TBI conditioning (cGy)
        none115 (37)
        ≤ 120078 (25)
        > 1200121 (38)
Post-transplant features
    acute GVHD grade
        0, I58 (18)
        II55 (18)
        III85 (27)
        IV61 (19)
        autologous/syngeneic49 (16)
        missing6 (2)
    incidence of infection
        adenovirus52 (17)
        cytomegalovirus63 (20)
        herpes simplex virus58 (18)
        varicella virus11 (4)
    received acyclovir246 (81)
    received amphotericin209 (67)
Acute kidney injury 2 wk before death128 (41)
    incidence of infection
        bacterial103 (33)
        fungal35 (11)
    incidence of dialysis82 (26)
    incidence of intubation119 (38)
    mean total serum bilirubin (mg/dl, median & range)4.9 (0.4 to 59.6)
    mean serum creatinine (mg/dl, median & range)1.56 (0.27 to 5.79)